PKC β pseudosubstrate

Name: PKC β pseudosubstrate
Brand: Tocris Bioscience
SKU: 1792

Tocris Bioscience, part of Bio-Techne | Catalog # 1792

COA / SDS

Selective cell-permeable PKC inhibitor peptide (attached to vector)

Discontinued Product

1792 has been discontinued. View all Protein Kinase C Inhibitors products.

Key Product Details

Description:	Selective cell-permeable PKC inhibitor peptide (attached to vector)
Alternative Names:	Protein kinase C beta pseudosubstrate
Molecular Weight:	3994.84

View Full Technical Details for PKC β pseudosubstrate

Technical Data
Citations

Biological Activity for PKC β pseudosubstrate

PKC β pseudosubstrate is a selective cell-permeable peptide inhibitor of protein kinase C (IC₅₀ ~ 0.5 μM). Consists of amino acids 19 - 31 of PKC pseudosubstrate domain linked by a disulphide bridge to a cell permeabilisation Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by intact cells, at 4 or 37°C, ensuring rapid and effective uptake of the inhibitor peptide. Once inside the cell, the disulphide bonds are subjected to reduction in the cytoplasm leading to release of the inhibitor peptide.

Technical Data for PKC β pseudosubstrate

M. Wt	3994.84
Formula	C₁₇₇H₂₉₄N₆₂O₃₈S₃
Single Letter Sequence	CRQIKIWFQNRRMKWKK CRFARKGALRQKNV* (Modifications: Disulfide bridge between 17 -1*)
Storage	Store at -20°C
CAS Number	172308-76-8
PubChem ID	90488712
InChi Key	KIWJPYSSLFMLBZ-OSCDWKIESA-N
Smiles	[H]N[C@@H](CSSC[C@H](N[H])C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for PKC β pseudosubstrate

References are publications that support the biological activity of the product.

House and Kemp Protein kinase C contains a pseudosubstrate prototope in its regulatory domain. Science 1987 PMID: 3686012
Theodore Intraneuronal delivery of protein kinase C pseudosubstrate leads to growth cone collapse. J.Neurosci. 1995 PMID: 7472470
Derossi The third helix of the antennapedia homeodomain translocates through biological membranes. J.Biol.Chem. 1994 PMID: 8144628

PKC β pseudosubstrate

Tocris Bioscience, part of Bio-Techne | Catalog # 1792

Key Product Details

Biological Activity for PKC β pseudosubstrate

Technical Data for PKC β pseudosubstrate

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for PKC β pseudosubstrate

Product Documents for PKC β pseudosubstrate

COA

Certificate of Analysis

SDS

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