PF CBP1

Name: PF CBP1
Brand: Tocris Bioscience
SKU: 5801

Tocris Bioscience, part of Bio-Techne | Catalog # 5801

COA / SDS

Selective CBP/p300 bromodomain inhibitor

Discontinued Product

5801 has been discontinued. View all Bromodomain Inhibitors products.

Key Product Details

Description:	Selective CBP/p300 bromodomain inhibitor
Chemical Name:	5-(Dimethyl-1,2-oxazol-4-yl)-1-[2-(morpholin-4-yl)ethyl]-2-[2-(4-propoxyphenyl)ethyl]-1H-1,3-benzodiazole
Purity:	≥98% (HPLC)
Molecular Weight:	488.62

View Full Technical Details for PF CBP1

Technical Data
Citations

Biological Activity for PF CBP1

Selective CBP/p300 bromodomain inhibitor (IC₅₀ values are 125 and 363 nM, respectively). Exhibits >100-fold selectivity for CBP over BRD4. Also exhibits selectivity over a panel of other bromodomains. Reduces LPS-induced IL-1β, IL-6 and IFN-β expression in macrophages in vitro. Also downregulates RGS4 expression in primary cortical neurons in vitro.

Negative Control also available.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

External Portal Informaiton

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of PF CBP1 is reviewed on the chemical probes website.

Technical Data for PF CBP1

M. Wt	488.62
Formula	C₂₉H₃₆N₄O₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1962928-21-7
PubChem ID	119081417
InChi Key	CGWBJJZOKGZCSJ-UHFFFAOYSA-N
Smiles	CC(ON=C1C)=C1C2=CC(N=C(CCC3=CC=C(OCCC)C=C3)N4CCN5CCOCC5)=C4C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for PF CBP1

References are publications that support the biological activity of the product.

Chekler Transcriptional profiling of a selective CREB binding protein bromodomain inhibitor highlights therapeutic opportunities. Chem.Biol. 2015 PMID: 26670081