Nigericin sodium salt
Tocris Bioscience, part of Bio-Techne | Catalog # 4312
Selective K+ ionophore
Product Description
Nigericin sodium salt is a potassium ionophore; it exchanges K+ for H+ across biological membranes in a similar manner to Valinomycin (Cat. No. 3373). Nigericin stimulates mitochondrial ATPase activity and disrupts membrane potential. Also acts as an ionophore for Pb2+ with no activity with other divalent cations. Antibiotic derived from Streptomyces hygroscopius.Product Specifications
Molecular Weight
746.94
Formula
C40H67NaO11
Storage
Store at -20°C
Chemical Name
(2R)-2-[(2R,3S,6R)-6-[[(2S,4R,5R,7R,9R,10R)- 2-[(2R,5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-Hydroxy- 6-(hydroxymethyl)-3,5-dimethyl-2-tetrahydropyranyl]-3-methyl- 2-tetrahydrofuranyl]-5-methyl-2-tetrahydrofuranyl]-9-methoxy- 2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl]methyl]-3-methyl- 2-tetrahydropyranyl]propanoic acid sodium salt
CAS Number
28643-80-3
PubChem ID
16760591
InChI Key
MOYOTUKECQMGHE-PDEFJWSRSA-M
SMILES
[Na+].[H][C@@]1(C[C@H](C)[C@@]([H])(O1)[C@]1(C)CC[C@@]([H])(O1)[C@]1(C)C[C@@H](C)[C@]2(O1)O[C@]([H])(C[C@@]1([H])CC[C@H](C)[C@@]([H])(O1)[C@@H](C)C([O-])=O)C[C@@H](OC)[C@H]2C)[C@@]1([H])O[C@@](O)(CO)[C@H](C)C[C@@H]1C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| Ethanol | 74.69 | 100 |
Preparing Stock Solutions
for Nigericin sodium salt
The following data is based on the product molecular weight 746.94
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.34 mL | 6.69 mL | 13.39 mL |
| 5 mM | 0.27 mL | 1.34 mL | 2.68 mL |
| 10 mM | 0.13 mL | 0.67 mL | 1.34 mL |
| 50 mM | 0.03 mL | 0.13 mL | 0.27 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Eytan Energy-linked transhydrogenase: Effects of Valinomycin and Nigericin on the ATP-driven transhydrogenase reaction catalyzed by reconstituted transhydrogenase-ATPase vesicles. J.Biol.Chem.
- Hamidinia The ionophore Nigericin transports Pb2+ with high activity and selectivity: A comparison to Monensin and Ionomycin. Biochemistry. 2004 PMID: 15595852
Product Specific Notices for Nigericin sodium salt
For research use only
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