Valinomycin

Name: Valinomycin
Brand: Tocris Bioscience
SKU: 3373
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3373

(2)

Citations (23)

COA / SDS

Selective K+ ionophore

Key Product Details

Description:	Selective K⁺ ionophore
Chemical Name:	Cyclo(D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl)
Purity:	≥90% (HPLC)
Molecular Weight:	1111.32

View Full Technical Details for Valinomycin

Technical Data
Citations / Reviews (2)

Biological Activity for Valinomycin

Valinomycin is a selective K⁺ ionophore (K_0.5 values are 48, 73, 75, 93 and 246 mM for K⁺, Rb⁺, Cs⁺, Na⁺ and Li⁺ respectively) that transports K⁺ across biological and artificial lipid membranes. Inhibits Ca²⁺-ATPase activity and induces apoptosis through mitochondrial membrane depolarization, caspase-3 activation and phosphatidylserine translocation in vitro.

Technical Data for Valinomycin

M. Wt	1111.32
Formula	C₅₄H₉₀N₆O₁₈
Storage	Store at -20°C
Purity	≥90% (HPLC)
CAS Number	2001-95-8
PubChem ID	3000706
InChi Key	FCFNRCROJUBPLU-DNDCDFAISA-N
Smiles	O=C([C@H](C)OC([C@@H]([C@@H](C)C)NC([C@H](OC([C@@H](NC([C@@H](O1)C)=O)[C@@H](C)C)=O)[C@@H](C)C)=O)=O)N[C@@H]([C@@H](C)C)C(O[C@H]([C@@H](C)C)C(N[C@@H](C(O[C@@H](C)C(N[C@@H]([C@H](C)C)C(O[C@H]([C@@H](C)C)C(N[C@H]([C@H](C)C)C1=O)=O)=O)=O)=O)[C@H](C)C)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Valinomycin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	27.78	25
	ethanol	27.78	25

Preparing Stock Solutions for Valinomycin

The following data is based on the product molecular weight 1111.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	3.60 mL	18.00 mL	35.99 mL
1.25 mM	0.72 mL	3.60 mL	7.20 mL
2.5 mM	0.36 mL	1.80 mL	3.60 mL
12.5 mM	0.07 mL	0.36 mL	0.72 mL

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Reconstitution Calculator

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References for Valinomycin

References are publications that support the biological activity of the product.

Abdalah Valinomycin-induced apoptosis in Chinese hamster ovary cells. Neurosci.Letts.
Rose and Jenkins The effects of the ionophore valinomycin on biomimetic solid supported lipid DPPTE/EPC membranes. Bioelectrochem.
Davidson and Berman Interaction of valinomycin and monovalent cations with the (Ca²⁺,Mg²⁺)-ATPase of skeletal muscle sarcoplasmic reticulum. J.Biol.Chem. 1985 PMID: 3158656