N,N-Dimethylsphingosine

Name: N , N -Dimethylsphingosine
Brand: Tocris Bioscience
SKU: 4640

Tocris Bioscience, part of Bio-Techne | Catalog # 4640

COA / SDS

Sphingosine kinase inhibitor

Discontinued Product

4640 has been discontinued. View all Sphingosine Kinase Inhibitors products.

Key Product Details

Description:	Sphingosine kinase inhibitor
Chemical Name:	(2S,3R,4E)-2-(Dimethylamino)-4-octadecene-1,3-diol
Purity:	≥98% (HPLC)
Molecular Weight:	327.55

View Full Technical Details for N,N-Dimethylsphingosine

Technical Data
Citations

Biological Activity for N,N-Dimethylsphingosine

N,N-Dimethylsphingosine is a competitive sphingosine kinase (SphK) inhibitor. Exhibits inhibitory activity in platelets and in cytosolic extracts from U937, Swiss 3T3 and PC12 cells. Selectively inhibits sphingosine phosphorylation; does not inhibit N-acylation, and displays no inhibitory effect on protein kinase C at concentrations that inhibit SphK. Increases the release of IL-1β and MCP-1 in cultured astrocytes; thought to mediate mechanical allodynia via this mechanism.

Technical Data for N,N-Dimethylsphingosine

M. Wt	327.55
Formula	C₂₀H₄₁NO₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	119567-63-4
PubChem ID	5282309
InChi Key	YRXOQXUDKDCXME-YIVRLKKSSA-N
Smiles	O[C@@H]([C@H](CO)N(C)C)/C=C/CCCCCCCCCCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for N,N-Dimethylsphingosine

References are publications that support the biological activity of the product.

Edsall N,N-dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide. Biochemistry 1998 PMID: 9737868
Yatomi N,N-dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human platelets. Biochemistry 1996 PMID: 8555236
Patti Metabolomics implicates altered sphingolipids in chronic pain of neuropathic origin. Nat.Chem.Biol. 2012 PMID: 22267119

N,N-Dimethylsphingosine

Tocris Bioscience, part of Bio-Techne | Catalog # 4640

Key Product Details

Biological Activity for N,N-Dimethylsphingosine

Technical Data for N,N-Dimethylsphingosine

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for N,N-Dimethylsphingosine

Product Documents for N,N-Dimethylsphingosine

COA

Certificate of Analysis

SDS

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