LY 393558

Name: LY 393558
Brand: Tocris Bioscience
SKU: 3350

Tocris Bioscience, part of Bio-Techne | Catalog # 3350

COA / SDS

Dual 5-HT1B and 5-HT1D antagonist; also 5-HT re-uptake inhibitor

Discontinued Product

3350 has been discontinued. View all 5-HT1B Receptor Antagonists products.

Key Product Details

Description:	Dual 5-HT_1B and 5-HT_1D antagonist; also 5-HT re-uptake inhibitor
Chemical Name:	1-[2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-1(2H)-pyridinyl]ethyl]-3,4-dihydro-3-(1-methylethyl)-6-(methylsulfonyl)-1H-2,1,3-benzothiadiazine-2,2-dioxide
Purity:	≥97% (HPLC)
Molecular Weight:	546.68

View Full Technical Details for LY 393558

Technical Data
Citations

Biological Activity for LY 393558

LY 393558 is a dual 5-HT_1B/1D receptor antagonist (pK_B values are 9.05 and 8.98 respectively) and 5-HT re-uptake inhibitor (pIC₅₀ = 8.48). Potently antagonizes terminal autoreceptor activity in vitro and increases extracellular 5-HT levels above those evoked by fluoxetine (Cat. No. 0927) in vivo. Also acts as an antagonist at 5-HT_2A and 5-HT_2B receptors (pK_i values are 7.29 and 7.35 respectively).

Technical Data for LY 393558

M. Wt	546.68
Formula	C₂₆H₃₁FN₄O₄S₂
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	271780-64-4
PubChem ID	10347428
InChi Key	QUSLYAPLTMMCFE-UHFFFAOYSA-N
Smiles	CC(C)N2S(N(CCN3CC=C(C4=CNC5=C4C=CC(F)=C5)CC3)C1=CC=C(S(=O)(C)=O)C=C1C2)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for LY 393558

References are publications that support the biological activity of the product.

Pullar In vitro activity of LY393558, an inhibitor of the 5-hydroxytryptamine transporter with 5-HT_1B/1D/2 receptor antagonist properties. Eur.J.Pharmacol. 2001 PMID: 11734182
Morecroft Functional interactions between 5-hydroxytryptamine receptors and the serotonin transporter in pulmonary arteries. J.Pharmacol.Exp.Ther. 2005 PMID: 15659538
Mitchell LY393558, a 5-hydroxytryptamine reuptake inhibitor and 5-HT_1B/1D receptor antagonist: effects on extracellular levels of 5-hydroxytryptamine in the guinea pig and rat. Eur.J.Pharmacol. 2001 PMID: 11734183

LY 393558

Tocris Bioscience, part of Bio-Techne | Catalog # 3350

Key Product Details

Biological Activity for LY 393558

Technical Data for LY 393558

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for LY 393558

Product Documents for LY 393558

COA

Certificate of Analysis

SDS

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