Fluoxetine hydrochloride

Product Description

Fluoxetine hydrochloride is a selective serotonin reuptake inhibitor. Binds to the human 5-HT transporter with a K_i of 0.9 nmol/l and is between 150- and 900-fold selective over 5-HT_1A, 5-HT_2A, H₁, α₁, α₂-adrenergic, and muscarinic receptors. Antidepressant. Induces differentiation of neuronal precursors, enhancing neuronal characteristics. Fluoxetine also inhibits assembly and activation of the NLRP3-ASC inflammasome and prevents degeneration of retinal pigmented epithelium (RPE) cells in an animal model of dry age-related macular degeneration (AMD).

Licensing Information

Sold with the permission of Eli Lilly and Company

Solubility

Preparing Stock Solutions for Fluoxetine hydrochloride

The following data is based on the product molecular weight 345.78

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.89 mL	14.46 mL	28.92 mL
5 mM	0.58 mL	2.89 mL	5.78 mL
10 mM	0.29 mL	1.45 mL	2.89 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Ambati Identification of fluoxetine as a direct NLRP3 inhibitor to treat atrophic macular degeneration. Proc.Natl.Acad.Sci.USA 2021 PMID: 34620711
• Chang Increased cellular turnover in response to fluox. in neuronal precursors derived from human embryonic stem cells. Int.J.Dev.Biol. 2010 PMID: 19598107
• Benfield Fluoxetine. A review of its pharmacodynamic properties, and therapeutic efficacy in depressive illness. Drugs 1986 PMID: 2878798
• Owens Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J.Pharmacol.Exp.Ther. 1997 PMID: 9400006
• Beck Fluoxetine selectively alters 5-hydroxytryptamine_1A and γ-aminobutyric acid_B receptor-mediated hyperpolarization in area CA1, but not area CA3, hippocampal pyramidal cells. J.Pharmacol.Exp.Ther. 1997 PMID: 9103487