Fluoxetine hydrochloride

Name: Fluoxetine hydrochloride
Brand: Tocris Bioscience
SKU: 0927
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0927

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Citations (79)

COA / SDS

5-HT reuptake inhibitor

Key Product Details

Description:	5-HT reuptake inhibitor
Chemical Name:	N-Methyl-3-[(4-trifluoromethyl)phenoxy]-3-phenylpropylamine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	345.78

View Full Technical Details for Fluoxetine hydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for Fluoxetine hydrochloride

Fluoxetine hydrochloride is a selective serotonin reuptake inhibitor. Binds to the human 5-HT transporter with a K_i of 0.9 nmol/l and is between 150- and 900-fold selective over 5-HT_1A, 5-HT_2A, H₁, α₁, α₂-adrenergic, and muscarinic receptors. Antidepressant. Induces differentiation of neuronal precursors, enhancing neuronal characteristics. Fluoxetine also inhibits assembly and activation of the NLRP3-ASC inflammasome and prevents degeneration of retinal pigmented epithelium (RPE) cells in an animal model of dry age-related macular degeneration (AMD).

Licensing Information

Sold with the permission of Eli Lilly and Company

Compound Libraries for Fluoxetine hydrochloride

Fluoxetine hydrochloride is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen FDA-Approved Drugs and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for Fluoxetine hydrochloride

M. Wt	345.78
Formula	C₁₇H₁₈F₃NO.HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	56296-78-7
PubChem ID	62857
InChi Key	GIYXAJPCNFJEHY-UHFFFAOYSA-N
Smiles	Cl.CNCCC(OC1=CC=C(C=C1)C(F)(F)F)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Fluoxetine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	34.58	100
	water	3.46	10

Preparing Stock Solutions for Fluoxetine hydrochloride

The following data is based on the product molecular weight 345.78.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.89 mL	14.46 mL	28.92 mL
5 mM	0.58 mL	2.89 mL	5.78 mL
10 mM	0.29 mL	1.45 mL	2.89 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

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References for Fluoxetine hydrochloride

References are publications that support the biological activity of the product.

Ambati Identification of fluoxetine as a direct NLRP3 inhibitor to treat atrophic macular degeneration. Proc.Natl.Acad.Sci.USA 2021 PMID: 34620711
Chang Increased cellular turnover in response to fluox. in neuronal precursors derived from human embryonic stem cells. Int.J.Dev.Biol. 2010 PMID: 19598107
Benfield Fluoxetine. A review of its pharmacodynamic properties, and therapeutic efficacy in depressive illness. Drugs 1986 PMID: 2878798
Owens Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J.Pharmacol.Exp.Ther. 1997 PMID: 9400006
Beck Fluoxetine selectively alters 5-hydroxytryptamine_1A and γ-aminobutyric acid_B receptor-mediated hyperpolarization in area CA1, but not area CA3, hippocampal pyramidal cells. J.Pharmacol.Exp.Ther. 1997 PMID: 9103487