Imipramine hydrochloride

Product Description

Imipramine hydrochloride is a potent tricyclic antidepressant; inhibits 5-HT and noradrenalin transporters (K_i values = 1.3-20 nM and 20-142 nM respectively). Increases autophagy, both alone and in combination with VEGF inhibitors or Temozolomide (Cat. No. 2706), to reduce the progression of glioma and slow the proliferation of other tumors. Reprograms tumor-associated macrophages from immunosuppressive to immunostimulatory via histamine receptor inhibition.

Solubility

Preparing Stock Solutions for Imipramine hydrochloride

The following data is based on the product molecular weight 316.87

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.31 mL	31.56 mL	63.12 mL
2.5 mM	1.26 mL	6.31 mL	12.62 mL
5 mM	0.63 mL	3.16 mL	6.31 mL
25 mM	0.13 mL	0.63 mL	1.26 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Chryplewicz Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity. Cancer Cell 2022 PMID: 36113478
• Wang Imipramine impedes glioma progression by inhibiting YAP as a Hippo pathway independent manner and synergizes with temozolomide. J.Cell.Mol.Med. 2021 PMID: 34469035