GSK J5
Tocris Bioscience, part of Bio-Techne | Catalog # 4689
Inactive isomer of GSK J4 (Cat. No. 4594); cell permeable
Discontinued Product
4689 has been discontinued.
An alternative/replacement product is available:
6935. View all Histone Demethylase Inhibitors products.
Key Product Details
Description
Inactive isomer of GSK J4 (Cat. No. 4594); cell permeable
Product Description
Inactive isomer of GSK J4; also cell permeable ester derivative of the inactive control, GSK J2.Active Analog also available.
Licensing Information
This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details of GSK J5, a cell permeable inactive isomer of GSK J1, please visit the GSK J1 probe summary on the SGC website.Product Specifications
Molecular Weight
417.50
Formula
C24H27N5O2
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
N-[2-(3-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester
CAS Number
1394854-51-3
PubChem ID
78243729
InChI Key
LQPGVGSKBNXQDU-UHFFFAOYSA-N
SMILES
O=C(CCNC1=NC(C2=CC=CN=C2)=NC(N3CCC(C=CC=C4)=C4CC3)=C1)OCC
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.75 | 100 | |
| Ethanol | 41.75 | 100 |
Preparing Stock Solutions
for GSK J5
The following data is based on the product molecular weight 417.50
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.40 mL | 11.98 mL | 23.95 mL |
| 5 mM | 0.48 mL | 2.40 mL | 4.79 mL |
| 10 mM | 0.24 mL | 1.20 mL | 2.40 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kruidenier A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature 2012 PMID: 22842901
Product Specific Notices for GSK J5
For research use only
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