GSK J2
Tocris Bioscience, part of Bio-Techne | Catalog # 4688
Inactive isomer of GSK J1 (Cat. No. 4593)
Key Product Details
Description
Inactive isomer of GSK J1 (Cat. No. 4593)
Product Description
GSK J2 is an inactive control of GSK J1 (IC50 > 100 μM for inhibition of JMJD3/UTX).Cell permeable ester derivative, GSK J5 and Active Analog also available.
Licensing Information
This compound is supplied in conjunction with the Structural Genomics Consortium. For further details of GSK J2, an inactive isomer of GSK J1, please visit the GSK J1 probe summary on the SGC website.Product Specifications
Molecular Weight
389.45
Formula
C22H23N5O2
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
N-[2-(3-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester
CAS Number
1394854-52-4
PubChem ID
73010924
InChI Key
LJIFOCRGDDQFJF-UHFFFAOYSA-N
SMILES
O=C(CCNC1=NC(C2=CC=CN=C2)=NC(N3CCC(C=CC=C4)=C4CC3)=C1)O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 19.47 | 50 | |
| DMSO | 38.94 | 100 |
Preparing Stock Solutions
for GSK J2
The following data is based on the product molecular weight 389.45
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.57 mL | 12.84 mL | 25.68 mL |
| 5 mM | 0.51 mL | 2.57 mL | 5.14 mL |
| 10 mM | 0.26 mL | 1.28 mL | 2.57 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.51 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kruidenier A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature 2012 PMID: 22842901
Product Specific Notices for GSK J2
For research use only
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