GSK J5 HCl
Tocris Bioscience, part of Bio-Techne | Catalog # 6935
Inactive isomer of GSK J4 (Cat. No. 4594); cell permeable
Key Product Details
Description
Inactive isomer of GSK J4 (Cat. No. 4594); cell permeable
Product Description
GSK J5 HCl is an inactive isomer of GSK J4 (Cat. No. 4594); also cell permeable ester derivative of the inactive control, GSK J2 (Cat. No. 4688).Active Analog also available.
Licensing Information
This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details of GSK J5, a cell permeable inactive isomer of GSK J1, please visit the GSK J1 probe summary on the SGC website.Product Specifications
Molecular Weight
453.97
Formula
C24H27N5O2.HCl
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
N-[2-(3-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester hydrochloride
CAS Number
1797983-32-4
PubChem ID
126456082
InChI Key
QQHQMHJAOKADED-UHFFFAOYSA-N
SMILES
O=C(CCNC1=NC(C2=CC=CN=C2)=NC(N3CCC(C=CC=C4)=C4CC3)=C1)OCC.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 22.7 | 50 |
Preparing Stock Solutions
for GSK J5 HCl
The following data is based on the product molecular weight 453.97
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.41 mL | 22.03 mL | 44.06 mL |
| 2.5 mM | 0.88 mL | 4.41 mL | 8.81 mL |
| 5 mM | 0.44 mL | 2.20 mL | 4.41 mL |
| 25 mM | 0.09 mL | 0.44 mL | 0.88 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kruidenier A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature 2012 PMID: 22842901
Product Specific Notices for GSK J5 HCl
For research use only
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