DMP 543

Product Description

DMP 543 is an acetylcholine release stimulator. Potently enhances K⁺-stimulated [³H]-ACh release from rat hippocampal slices (EC₅₀ = 700 nM), and increases release of dopamine and glutamate (EC₅₀ values are 0.25 and 0.22 μM, respectively). Orally active in vivo; increases ACh levels in rats (with a minimum effective dose of 1 mg/kg) and exerts a long duration of action. More potent than linopirdine (Cat. No. 1999) both in vitro and in vivo. Also K⁺ channel blocker.

Solubility

Preparing Stock Solutions for DMP 543

The following data is based on the product molecular weight 412.44

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.42 mL	12.12 mL	24.25 mL
5 mM	0.48 mL	2.42 mL	4.85 mL
10 mM	0.24 mL	1.21 mL	2.42 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Earl 2-Fluoro-4-pyridinylmethyl analogues of linopirdine as orally active acetylcholine release-enhancing agents with good efficacy and duration of action. J.Med.Chem. 1998 PMID: 9804701
• Zaczek Two new potent neurotransmitter release enhancers, 10,10-Bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-Bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J.Pharmacol.Exp.Ther. 1998 PMID: 9580619