Linopirdine dihydrochloride is a blocker of K_V7 (KCNQ) voltage-gated potassium channels; blocks K_V7.1 + 7.3 (KCNQ2 + 3) / M-currents (IC₅₀ = 4 - 7 μM) and K_V7.1 (KCNQ1) homomeric channels (IC₅₀ = 8.9 μM). Augments hippocampal ACh release and is a cognitive enhancer following oral administration in vivo.

Product Specifications

Molecular Weight

464.39

Formula

C₂₆H₂₁N₃O.2HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

1,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one dihydrochloride

CAS Number

113168-57-3

PubChem ID

14209557

InChI Key

ZEVVHCGTTNRYOY-UHFFFAOYSA-N

SMILES

Cl.Cl.O=C1N(C2=CC=CC=C2C1(CC1=CC=NC=C1)CC1=CC=NC=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	46.44	100
	DMSO	46.44	100

Preparing Stock Solutions for Linopirdine dihydrochloride

The following data is based on the product molecular weight 464.39

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.15 mL	10.77 mL	21.53 mL
5 mM	0.43 mL	2.15 mL	4.31 mL
10 mM	0.22 mL	1.08 mL	2.15 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

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Background References

References are publications that support the biological activity of the product.

Wang KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science 1998 PMID: 9836639
Zaczek Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J.Pharmacol.Exp.Ther. 1998 PMID: 9580619
Schnee and Brown Selectivity of linopirdine (DuP 966), a neurotransmitter release enhancer, in blocking voltage-dependent and calcium-activated potassium currents in hippocampal neurons. J.Pharmacol.Exp.Ther. 1998 PMID: 9694925

Linopirdine dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 1999

Key Product Details

Description

Alternative Names

View all Voltage-gated Potassium Channel Blockers »

Product Description