cis-6-Hydroxynorketamine hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 5982
Enhances AMPA currents: antidepressant
Key Product Details
Description
Enhances AMPA currents: antidepressant
Product Description
cis-6-Hydroxynorketamine hydrochloride is a metabolite of ketamine. Increases AMPA receptor-mediated excitatory post-synaptic potentials in the CA1 region of hippocampal slices. Exhibits antidepressive effects in vivo.2S,6S-enantiomer and 2R,6R-enantiomer also available.
Product Specifications
Molecular Weight
276.16
Formula
C12H14ClNO2.HCl
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
cis-2-Amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride
CAS Number
2319601-04-0
PubChem ID
121513910
InChI Key
ZQJVHBJDLMIKJK-MHDYBILJSA-N
SMILES
ClC1=C([C@@]2(N)C([C@H](O)CCC2)=O)C=CC=C1.ClC3=C([C@]4(N)C([C@@H](O)CCC4)=O)C=CC=C3.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 27.62 | 100 | |
| DMSO | 27.62 | 100 |
Preparing Stock Solutions
for cis-6-Hydroxynorketamine hydrochloride
The following data is based on the product molecular weight 276.16
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.62 mL | 18.11 mL | 36.21 mL |
| 5 mM | 0.72 mL | 3.62 mL | 7.24 mL |
| 10 mM | 0.36 mL | 1.81 mL | 3.62 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.72 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Leung and Baillie Comparative pharmacology in the rat of KA and its two principal metabolites, norKA and (Z)-6-hydroxynorKA. J.Med.Chem. 1986 PMID: 3783598
- Zanos NMDAR inhibition-independent antidepressant actions of KA metabolites. Nature 2016 PMID: 27144355
Product Specific Notices for cis-6-Hydroxynorketamine hydrochloride
For research use only
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