2R,6R-Hydroxynorketamine hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 6094
Enhances AMPA currents; decreases D-serine (a NMDA co-agonist); lacks ketamine-related side effects
Key Product Details
Description
Enhances AMPA currents; decreases D-serine (a NMDA co-agonist); lacks ketamine-related side effects
Product Description
2R,6R-Hydroxynorketamine hydrochloride is a ketamine metabolite. It enhances AMPA receptor-mediated excitatory post-synaptic potentials in the CA1 region of hippocampal slices and decreases intracellular D-serine (a NMDA co-agonist) concentrations in PC-12 cells (IC50 = 0.68 nM). 2R,6R-Hydroxynorketamine upregulates KCNQ2 channels in mouse ventral hippocampal glutamatergic neurons in vitro and in vivo. Exerts antidepressant effects in mice. Lacks ketamine-related side effects.2S,6S-Enantiomer and Racemate also available.
Licensing Information
Sold under license from the NIH, US patent 62/313,309Product Specifications
Molecular Weight
276.16
Formula
C12H14ClNO2.HCl
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
(2R,6R)-2-Amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride
CAS Number
1430202-69-9
PubChem ID
121513910
InChI Key
ZQJVHBJDLMIKJK-MHDYBILJSA-N
SMILES
ClC1=C([C@@]2(N)C([C@H](O)CCC2)=O)C=CC=C1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 13.81 | 50 | |
| DMSO | 27.62 | 100 |
Preparing Stock Solutions
for 2R,6R-Hydroxynorketamine hydrochloride
The following data is based on the product molecular weight 276.16
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.62 mL | 18.11 mL | 36.21 mL |
| 5 mM | 0.72 mL | 3.62 mL | 7.24 mL |
| 10 mM | 0.36 mL | 1.81 mL | 3.62 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.72 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Zanos NMDAR inhibition-independent antidepressant actions of KA metabolites. Nature 2016 PMID: 27144355
- Lopez Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2. Neuron 2022 PMID: 35649415
- Singh KA metabolites enantioselectively decrease intracellular D-serine concentrations in PC-12 cells. PLoS One 2016 PMID: 27096720
Product Specific Notices for 2R,6R-Hydroxynorketamine hydrochloride
For research use only
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