BF 738735
Tocris Bioscience, part of Bio-Techne | Catalog # 6246
Potent and selective PI 4-kinase IIIβ inhibitor; broad spectrum enterovirus replication inhibitor
Discontinued Product
6246 has been discontinued.
View all Other Kinase Inhibitors products.
Key Product Details
Description
Potent and selective PI 4-kinase IIIβ inhibitor; broad spectrum enterovirus replication inhibitor
Product Description
BF 738735 is a potent and selective ATP-competitive phosphatidylinositol 4-kinase III beta (PI 4-KIIIβ) inhibitor (IC50 = 5.7 nM). Displays approximately 200-fold selectivity over PI 4-KIIIα. Broad spectrum enterovirus replication inhibitor.Product Specifications
Molecular Weight
426.47
Formula
C21H19FN4O3S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-Fluoro-4-[2-methyl-8-[[[3-(methylsulfonyl)phenyl]methyl]amino]imidazo[1,2-a]pyrazin-3-yl]phenol
CAS Number
1436383-95-7
PubChem ID
135742054
InChI Key
IMHZCCZYPHJVMS-UHFFFAOYSA-N
SMILES
CC1=C(C2=CC(F)=C(C=C2)O)N3C=CN=C(C3=N1)NCC4=CC(S(C)(=O)=O)=CC=C4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.65 | 100 | |
| Ethanol | 8.53 | 20 |
Preparing Stock Solutions
for BF 738735
The following data is based on the product molecular weight 426.47
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.34 mL | 11.72 mL | 23.45 mL |
| 5 mM | 0.47 mL | 2.34 mL | 4.69 mL |
| 10 mM | 0.23 mL | 1.17 mL | 2.34 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.47 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- van der Schaar A novel, broad-spectrum inhibitor of enterovirus replication that targets host cell factor phosphatidylinositol 4-kinase III. Antimicrob.Agents Chemother.
- MacLeod Identification of a series of compounds with potent antiviral activity for the treatment of enterovirus infections. ACS Med.Chem.Lett. 2013 PMID: 24900715
Product Specific Notices for BF 738735
For research use only
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