Rat CXCR2/IL-8RB (NP_058879) VersaClone cDNA
R&D Systems, part of Bio-Techne | Catalog # RDC0242
Key Product Details
Species
Rat
Accession Number
Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: CXCR2/IL-8RB
CXCR2/IL-8RB is a member of the CXC chemokine receptor subfamily. Similar to other chemokine receptors, it is a G protein-coupled receptor (GPCR). Human CXCR2/IL-8RB is 360 amino acids (aa) in length with a predicted molecular weight of 41 kDa. The human protein shares 71% aa sequence identity with the mouse and rat protein. CXCR2/IL-8RB is expressed on neutrophils and activates neutrophil chemotaxis. Similar to the closely related CXCR1/IL-8RA, CXCR2/IL-8RB binds and mediates CXCL8/IL-8-induced neutrophil activation. It also binds additional CXC chemokine ligands that contain an ELR aa motif. CXCR2/IL-8RB is implicated in neurological and pulmonary inflammatory diseases and injury. As such, it is a therapeutic target of interest in inflammatory disease and cancer.
Long Name
Interleukin 8 Receptor B
Alternate Names
CD182, CDw128b, CMKAR2, CXCR-2, IL-8 RB, IL8RB
Gene Symbol
CXCR2
UniProt
Additional CXCR2/IL-8RB Products
Product Documents for Rat CXCR2/IL-8RB (NP_058879) VersaClone cDNA
Product Specific Notices for Rat CXCR2/IL-8RB (NP_058879) VersaClone cDNA
For research use only
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