Niemann-Pick C1 Antibody (24GB620)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-50543

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NBP3-50543-20ul
NBP3-50543-100ul
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot, Flow Cytometry, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Monoclonal Rabbit IgG Clone # 24GB620

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Niemann-Pick Type C1/NPC1 Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human Niemann-Pick C1 (Uniprot: O15118)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Niemann-Pick C1 Antibody (24GB620)

Niemann-Pick C1 Antibody (24GB620)

Immunocytochemistry/ Immunofluorescence: Niemann-Pick C1 Antibody (24GB620)[NBP3-50543] -

Immunocytochemical staining of HT-1080 cells with Niemann-Pick C1 antibody (1:1,000). Nuclei were stained blue with DAPI; Niemann-Pick C1 was stained magenta with Alexa Fluor(R) 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 um.
Niemann-Pick C1 Antibody (24GB620)

Flow Cytometry: Niemann-Pick C1 Antibody (24GB620)[NBP3-50543] -

Flow cytometric analysis of Niemann-Pick C1expression in HT-1080 cells using Niemann-Pick C1 antibody (1:2,000). Green, isotype control; red, NPC1.
Niemann-Pick C1 Antibody (24GB620)

Western Blot: Niemann-Pick C1 Antibody (24GB620)[NBP3-50543] -

Western blotting analysis using Niemann-Pick C1 antibody (1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (1:20,000) respectively. Image was developed using FeQ(TM) ECL Substrate Kit.

Applications for Niemann-Pick C1 Antibody (24GB620)

Application
Recommended Usage

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.4), 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Niemann-Pick Type C1/NPC1

Niemann-Pick type C1 (NPC1) is a member of a family of genes encoding membrane-bound proteins containing putative sterol sensing domains. The protein regulates cholesterol transport from late endosomes-lysosomes to other intracellular compartments. NPC1 overexpression increases both the rate of trafficking of low density lipoprotein cholesterol to the endoplasmic reticulum and the rate of delivery of endosomal cholesterol to the plasma membrane. NPC disease is an inherited neurovisceral lipid storage disorder of unesterified cholesterol accumulation in lysosomes. It is characterized by progressive neural and liver degeneration, resulting from inactivating mutations in NPC1, in most cases.

Alternate Names

NPC1, SLC65A1

Gene Symbol

NPC1

Additional Niemann-Pick Type C1/NPC1 Products

Product Documents for Niemann-Pick C1 Antibody (24GB620)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Niemann-Pick C1 Antibody (24GB620)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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