Lymphotoxin beta receptor (LT betaR), also known as TNF RIII and TNF R-related protein (TNF Rrp) is a member of the TNF receptor superfamily, designated TNFRSF3. Human LT betaR cDNA encodes a 435 amino acid (aa) residue type I membrane protein with a putative 30 aa residue signal peptide, a 193 aa residue extracellular domain and a 171 aa residue cytoplasmic domain. The extracellular domain of LT betaR contains four cysteine-rich motifs characteristic of the TNF receptor superfamily. The cytoplasmic region of LT betaR shares little sequence similarity with other TNF receptor family members, suggesting that different signaling mechanisms may be used. LT betaR is expressed in a variety of tissues including visceral and lymphoid tissues. LT betaR is also expressed by cell lines of monocytic, epithelial, and fibroblastic origins but not by T and B lymphocytes. Human and mouse LT betaR share 76% aa sequence homology. The TNF family ligands that have been shown to bind and activate LT betaR include LIGHT (also a ligand for HVEM) and the heterotrimeric lymphotoxin LT alpha1/ beta2 or LT alpha2/ beta1. Depending on the cell type, activation of LT betaR has been shown to induce NF kappaB activation, chemokine production, growth arrest, and apoptosis. In vivo, LT betaR has been shown to play a critical role in controlling cellular immune functions and lymphoid organogenesis.

Long Name

Lymphotoxin beta Receptor

Alternate Names

LTBR, LymphotoxinbR, TNF RIII, TNF Rrp, TNFRSF3

Entrez Gene IDs

4055 (Human); 17000 (Mouse); 297604 (Rat); 102135920 (Cynomolgus Monkey); 712550 (Rhesus Macaque)

Gene Symbol

LTBR

UniProt

P50284

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This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

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Mouse Lymphotoxin betaR/TNFRSF3 Alexa Fluor® 488-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # AF10081G

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Background: Lymphotoxin beta R/TNFRSF3