Anti- Aducanumab (Anti-Idiotype) Antibody
R&D Systems, part of Bio-Techne | Catalog # MAB10180
Conjugate
Catalog #
Key Product Details
Species Reactivity
Multi-Species
Applications
Western Blot
Label
Unconjugated
Antibody Source
Recombinant Monoclonal Rabbit IgG Clone # 2374E
Product Specifications
Immunogen
Full length Aducanumab
Specificity
Detects human Aducanumab in direct ELISAs and Western blots. In Western blots, no cross-reactivity with Brentuximab and Ipilimumab is observed.
Clonality
Monoclonal
Host
Rabbit
Isotype
IgG
Scientific Data Images for Anti- Aducanumab (Anti-Idiotype) Antibody
Detection of Aducanumab by Western Blot.
Western blot shows Brentuximab (negative control), Aducanumab and Ipilimumab (negative control) biosimilars. PVDF membrane was probed with 2 µg/mL of Anti-Aducanumab (Anti-Idiotype) Monoclonal Antibody (Catalog # MAB10180) followed by HRP-conjugated Anti-Rabbit IgG Secondary Antibody (HAF008). A specific band was detected for Aducanumab at approximately 250 kDa (as indicated). GAPDH (MAB5718) is shown as a loading control. This experiment was conducted under non-reducing conditions and using Immunoblot Buffer Group 1.Applications for Anti- Aducanumab (Anti-Idiotype) Antibody
Application
Recommended Usage
Western Blot
2 µg/mL
Sample: Aducanumab
under non-reducing conditions only
Sample: Aducanumab
under non-reducing conditions only
Formulation, Preparation, and Storage
Purification
Protein A or G purified from cell culture supernatant
Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Aducanumab
The anti-Aducanumab antibody is an anti-Idiotype antibody raised against and selected for the antigenic determinants of the variable region of Aducanumab. The antibody has been tested against a broad range of other biosimilars to ensure specificity. This highly specialized anti-idiotypic antibody can be used in a variety of pharmacokinetic (PK) assay formats.
Additional Aducanumab Products
Product Documents for Anti- Aducanumab (Anti-Idiotype) Antibody
Product Specific Notices for Anti- Aducanumab (Anti-Idiotype) Antibody
For research use only
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