TRPML Channel Activators: Small Molecules and Peptides

TRPML1 is a cation-selective ion channel that is important for sorting/transport of endosomes in the late endocytotic pathway and specifically fusion between late endosome-lysosome hybrid vesicles. Therefore they are thought to control delivery of cellular material to lysosomes. TRPML1 has also been implicated in lysosomal dysfunction, which is associated with increased autophagy. Mutations in the gene encoding the TRPML1 channel (MCOLN1) are the cause of the neurodegenerative disorder ...