ML SA1
Tocris Bioscience, part of Bio-Techne | Catalog # 4746
Activator of TRPML channels
Product Description
ML SA1 is an activator of TRPML channels (TRPML1, 2 and 3); does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels. Induces TRPML-mediated Ca2+ release from lysosomes; activity corrects trafficking defects and reduces cholesterol accumulation in Niemann-Pick type C macrophages. Activation of TRPML1 by ML SA1 causes membrane accumulation of aquaporin-3 and -5, and significant depolymerization of the actin cytoskeleton, in human lymphatic endothelial cells (HLECs).Product Specifications
Molecular Weight
362.42
Formula
C22H22N2O3
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2-[2-(3,4-Dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione
CAS Number
332382-54-4
PubChem ID
2880983
InChI Key
KDDHBJICVBONAX-UHFFFAOYSA-N
SMILES
CC2CC(C)(C)N(C(CN3C(C(C=CC=C4)=C4C3=O)=O)=O)C1=CC=CC=C12
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.25 | 20 |
Preparing Stock Solutions
for ML SA1
The following data is based on the product molecular weight 362.42
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 13.80 mL | 68.98 mL | 137.96 mL |
| 1 mM | 2.76 mL | 13.80 mL | 27.59 mL |
| 2 mM | 1.38 mL | 6.90 mL | 13.80 mL |
| 10 mM | 0.28 mL | 1.38 mL | 2.76 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Weiss Cross-talk between TRPML1 channel, lipids and lysosomal storage diseases. Commun.Integr.Biol. 2012 PMID: 22808310
- Yang TRPML1 acts as a predisposing factor in lymphedema development by regulating the subcellular localization of aquaporin-3, -5. PLoS One 2024 PMID: 39637010
- Shen Lipid storage disorders block lysosomal trafficking by inhibiting TRP channel and calcium release. Nat.Commun. 2012 PMID: 22415822
Product Specific Notices for ML SA1
For research use only
Loading...
Loading...