TRF-2 Products
RF2 (telomeric repeat-binding factor 2; also telomeric DNA-binding protein) is a 55-60 kDa, ubiquitously expressed nuclear protein that participates in telomere homeostasis. TRF2 binds as a dimer to TTAGGG repeats at ends of chromosomes (telomeres), where it blocks inappropriate activation of the ATM/p53 pathway. It also collaborates with TRF1 to promote normal telomere length. TRF2 has been found up regulated in several human cancers. Human TRF2 is 500 amino acids (aa) in length. It contains an N-terminal Arg-rich region (aa 13-30), a dimerization domain (aa 46-112), an NLS (aa 329-333), and a DNA binding HTH myb-type domain (aa 442-499). There is one potential alternate start site 42 aa upstream of the standard start site, and one splice form that shows a 13 aa substitution for aa 239-500. Over aa 78-238, human TRF2 shares 96% aa identity with mouse TRF2.
145 results for "TRF-2" in Products
145 results for "TRF-2" in Products
TRF-2 Products
RF2 (telomeric repeat-binding factor 2; also telomeric DNA-binding protein) is a 55-60 kDa, ubiquitously expressed nuclear protein that participates in telomere homeostasis. TRF2 binds as a dimer to TTAGGG repeats at ends of chromosomes (telomeres), where it blocks inappropriate activation of the ATM/p53 pathway. It also collaborates with TRF1 to promote normal telomere length. TRF2 has been found up regulated in several human cancers. Human TRF2 is 500 amino acids (aa) in length. It contains an N-terminal Arg-rich region (aa 13-30), a dimerization domain (aa 46-112), an NLS (aa 329-333), and a DNA binding HTH myb-type domain (aa 442-499). There is one potential alternate start site 42 aa upstream of the standard start site, and one splice form that shows a 13 aa substitution for aa 239-500. Over aa 78-238, human TRF2 shares 96% aa identity with mouse TRF2.
| Reactivity: | Human, Mouse, Rat, Primate, Chinese Hamster |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ELISA, ICC/IF, Flow, +6 More |
![Immunocytochemistry/ Immunofluorescence: TRF-2 Antibody - BSA Free [NB110-57130]](https://resources.bio-techne.com/images/products/TRF-2-Antibody-Immunocytochemistry-Immunofluorescence-NB110-57130-img0011.jpg "Immunocytochemistry/ Immunofluorescence: TRF-2 Antibody - BSA Free [NB110-57130]")
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #689524 |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #689524 |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #689524 |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #689524 |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #689524 |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #689524 |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #689524 |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #689524 |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #689524 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat, Marsupial, Deer, +1 More |
| Details: | Mouse IgG1 kappa Monoclonal Clone #4A794.15 |
| Applications: | IHC, WB, ELISA, ICC/IF, Flow, +5 More |
![Simple Western: TRF-2 Antibody (4A794.15)BSA Free [NB100-56506]](https://resources.bio-techne.com/images/products/TRF-2-Antibody-4A794-15-Simple-Western-NB100-56506-img0010.jpg "Simple Western: TRF-2 Antibody (4A794.15)BSA Free [NB100-56506]")
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF, Flow, IP, +2 More |
![Immunoprecipitation: TRF-2 Antibody [NB100-56694]](https://resources.bio-techne.com/images/products/TRF-2-Antibody-Immunoprecipitation-NB100-56694-img0006.jpg "Immunoprecipitation: TRF-2 Antibody [NB100-56694]")
| Reactivity: | Human, Mouse, Rat, Marsupial, Deer |
| Details: | Mouse IgG1 kappa Monoclonal Clone #4A794.15 |
| Applications: | IHC, WB, ELISA, ICC/IF, Flow, +3 More |
![Western Blot: TRF-2 Antibody (4A794.15)Azide Free [NBP2-33212]](https://resources.bio-techne.com/images/products/TRF-2-Antibody-4A794-15-Azide-Free-Western-Blot-NBP2-33212-img0002.jpg "Western Blot: TRF-2 Antibody (4A794.15)Azide Free [NBP2-33212]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF |
![Immunocytochemistry/ Immunofluorescence: TRF-2 Antibody [NBP1-86911]](https://resources.bio-techne.com/images/products/TRF-2-Antibody-Immunocytochemistry-Immunofluorescence-NBP1-86911-img0009.jpg "Immunocytochemistry/ Immunofluorescence: TRF-2 Antibody [NBP1-86911]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC |
![TRF-2 Antibody - BSA Free Immunohistochemistry-Paraffin: TRF-2 Antibody - BSA Free [NBP1-86910]](https://resources.bio-techne.com/images/products/nbp1-86910_rabbit-polyclonal-trf-2-antibody-304202513131187.jpg "Immunohistochemistry-Paraffin: TRF-2 Antibody - BSA Free [NBP1-86910]")
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #JE37-57 |
| Applications: | IHC, WB, ICC/IF |
