Tau: Small Molecules and Peptides

The Tau protein is a microtubule-associated protein expressed primarily in axons of central nervous system neurons. Tau is also detected in oligodendrocytes, the somatodendritic compartment within neurons, and some non-neuronal tissues. In healthy neurons, Tau promotes the assembly and stabilization of microtubules along with other MAP proteins, especially MAP1B. It is believed that other proteins can compensate for loss of Tau protein function as Tau knockout mice are viable and show no signs ...