Smad3 Products
Smads are a family of intracellular proteins that mediate signaling by members of the TGF-beta superfamily. Smads are divided into three distinct subgroups based on their different roles in TGF-beta family signal transduction: R-Smads (receptor-regulated), Co-Smads (common partner), and I-Smads (inhibitory). In general, activation of TGF-beta superfamily serine/threonine kinase receptors leads to the phosphorylation of R-Smads (Smads1, 2, 3, 5, and 8). This is followed by recruitment of the Co-Smad (Smad-4) into an R-Smad/Co-Smad complex that translocates to the nucleus to regulate gene expression. I-Smads (Smad6 and Smad7) antagonize this signaling pathway by preventing R-Smads from interacting with the receptor, or by competing with Co-Smads for the generation of R-Smad/Co-Smad complexes.
141 results for "Smad3" in Products
141 results for "Smad3" in Products
Smad3 Products
Smads are a family of intracellular proteins that mediate signaling by members of the TGF-beta superfamily. Smads are divided into three distinct subgroups based on their different roles in TGF-beta family signal transduction: R-Smads (receptor-regulated), Co-Smads (common partner), and I-Smads (inhibitory). In general, activation of TGF-beta superfamily serine/threonine kinase receptors leads to the phosphorylation of R-Smads (Smads1, 2, 3, 5, and 8). This is followed by recruitment of the Co-Smad (Smad-4) into an R-Smad/Co-Smad complex that translocates to the nucleus to regulate gene expression. I-Smads (Smad6 and Smad7) antagonize this signaling pathway by preventing R-Smads from interacting with the receptor, or by competing with Co-Smads for the generation of R-Smad/Co-Smad complexes.
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #PCRP-SMAD3-1A2 |
| Applications: | ICC/IF, Flow, MA |
![Immunocytochemistry/ Immunofluorescence: Smad3 Antibody (PCRP-SMAD3-1A2) [NBP3-07255]](https://resources.bio-techne.com/images/products/Smad3-Antibody-PCRP-SMAD3-1A2-Immunocytochemistry-Immunofluorescence-NBP3-07255-img0003.jpg "Immunocytochemistry/ Immunofluorescence: Smad3 Antibody (PCRP-SMAD3-1A2) [NBP3-07255]")
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #PCRP-SMAD3-1A2 |
| Applications: | ICC/IF, Flow, MA |
![Immunocytochemistry/ Immunofluorescence: Smad3 Antibody (PCRP-SMAD3-1A2) - Azide and BSA Free [NBP3-08287]](https://resources.bio-techne.com/images/products/Smad3-Antibody-PCRP-SMAD3-1A2-Immunocytochemistry-Immunofluorescence-NBP3-08287-img0002.jpg "Immunocytochemistry/ Immunofluorescence: Smad3 Antibody (PCRP-SMAD3-1A2) - Azide and BSA Free [NBP3-08287]")
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #PCRP-SMAD3-1A2 |
| Applications: | ICC/IF, Flow, MA |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #PCRP-SMAD3-1A2 |
| Applications: | ICC/IF, Flow, MA |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #PCRP-SMAD3-1A2 |
| Applications: | ICC/IF, Flow, MA |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #PCRP-SMAD3-1A2 |
| Applications: | ICC/IF, Flow, MA |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #PCRP-SMAD3-1A2 |
| Applications: | ICC/IF, Flow, MA |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #PCRP-SMAD3-1A2 |
| Applications: | ICC/IF, Flow, MA |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #PCRP-SMAD3-1A2 |
| Applications: | ICC/IF, Flow, MA |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #PCRP-SMAD3-1A2 |
| Applications: | ICC/IF, Flow, MA |
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ELISA, ICC/IF, Flow, +1 More |
![Western Blot: Smad3 [p Ser423, p Ser425] Antibody [NBP1-77836]](https://resources.bio-techne.com/images/products/Smad3-[p-Ser423--p-Ser425]-Antibody-Western-Blot-NBP1-77836-img0005.jpg "Western Blot: Smad3 [p Ser423, p Ser425] Antibody [NBP1-77836]")
| Reactivity: | Human, Mouse, Rat, Canine, Bovine, +2 More |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF, Simple Western |
![Western Blot: Smad3 Antibody [NB100-56479]](https://resources.bio-techne.com/images/products/Smad3-Antibody-Western-Blot-NB100-56479-img0008.jpg "Western Blot: Smad3 Antibody [NB100-56479]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #1T1Q9 |
| Applications: | IHC, WB, IP, KO |
![SDS-PAGE: Recombinant Human Smad3 His Protein [NBP1-30284]](https://resources.bio-techne.com/images/products/Recombinant-Mouse-Smad3-Protein-SDS-Page-NBP1-30284-img0002.jpg "SDS-PAGE: Recombinant Human Smad3 His Protein [NBP1-30284]")
| Reactivity: | Human |
| Details: | Rat IgG1 Monoclonal Clone #378611 |
| Applications: | IHC, CyTOF-ready, ICC, ICFlow |
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Monoclonal Clone #ST0493 |
| Applications: | IHC, WB, ICC/IF |
| Reactivity: | Human, Rat |
| Details: | Mouse IgG1 kappa Monoclonal Clone #7F3 |
| Applications: | IHC, WB, ELISA, ICC/IF, Func |
![Western Blot: Smad3 Antibody (7F3) [H00004088-M02]](https://resources.bio-techne.com/images/products/Smad3-Antibody-7F3-Western-Blot-H00004088-M02-img0024.jpg "Western Blot: Smad3 Antibody (7F3) [H00004088-M02]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF, Flow, IP, +1 More |
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ELISA, ICC/IF |
![Western Blot: Smad3 [p Thr179] Antibody [NBP2-19126]](https://resources.bio-techne.com/images/products/Smad3-[p-Thr179]-Antibody-Western-Blot-NBP2-19126-img0001.jpg "Western Blot: Smad3 [p Thr179] Antibody [NBP2-19126]")
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Monoclonal Clone #SR1995 |
| Applications: | IHC, WB, ICC/IF |
| Reactivity: | Human |
| Details: | Rat IgG1 Monoclonal Clone #378611 |
| Applications: | ICFlow |
| Reactivity: | Human |
| Details: | Rat IgG1 Monoclonal Clone #378611 |
| Applications: | ICFlow |
| Reactivity: | Human |
| Details: | Rat IgG1 Monoclonal Clone #378611 |
| Applications: | ICFlow |
| Reactivity: | Human |
| Details: | Rat IgG1 Monoclonal Clone #378611 |
| Applications: | ICFlow |
| Reactivity: | Human |
| Details: | Rat IgG1 Monoclonal Clone #378611 |
| Applications: | ICFlow |