RIG-I Products
RIG-I-like Receptors (RLRs) are a subset of cytosolic pattern recognition receptors that are essential for antiviral immunity. The RLR family consists of three members: RIG-I, MDA5, and LGP2. Unlike the NOD-like Receptor (NLR) family proteins, the RLR proteins are RNA helicases that recognize viral RNA. RIG-I and MDA5 contain two N-terminal caspase recruitment domains (CARDs), an internal RNA helicase domain, and a C-terminal repressor/RNA-binding domain. Signaling through both receptors activates NF-kappa B- and IRF3-/IRF7-dependent gene expression, leading to the secretion of pro-inflammatory cytokines, and type I and type III interferons, respectively. Unlike RIG-I and MDA5, LGP2 does not contain a CARD domain at its N-terminal end and has not been shown to bind to RNA. As a result, LGP2 is currently thought to serve as a regulator of RIG-I and MDA5 signaling.
147 results for "RIG-I" in Products
147 results for "RIG-I" in Products
RIG-I Products
RIG-I-like Receptors (RLRs) are a subset of cytosolic pattern recognition receptors that are essential for antiviral immunity. The RLR family consists of three members: RIG-I, MDA5, and LGP2. Unlike the NOD-like Receptor (NLR) family proteins, the RLR proteins are RNA helicases that recognize viral RNA. RIG-I and MDA5 contain two N-terminal caspase recruitment domains (CARDs), an internal RNA helicase domain, and a C-terminal repressor/RNA-binding domain. Signaling through both receptors activates NF-kappa B- and IRF3-/IRF7-dependent gene expression, leading to the secretion of pro-inflammatory cytokines, and type I and type III interferons, respectively. Unlike RIG-I and MDA5, LGP2 does not contain a CARD domain at its N-terminal end and has not been shown to bind to RNA. As a result, LGP2 is currently thought to serve as a regulator of RIG-I and MDA5 signaling.
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ELISA, ICC/IF, Simple Western |
![Western Blot: RIG-I AntibodyBSA Free [NBP1-76732]](https://resources.bio-techne.com/images/products/RIG-I-Antibody-Western-Blot-NBP1-76732-img0004.jpg "Western Blot: RIG-I AntibodyBSA Free [NBP1-76732]")
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Mouse IgG2A Monoclonal Clone #OTI6C1 |
| Applications: | IHC, WB, ICC/IF |
![Western Blot: RIG-I Antibody (OTI6C1) [NBP2-45678]](https://resources.bio-techne.com/images/products/RIG-I-Antibody-OTI6C1-Western-Blot-NBP2-45678-img0007.jpg "Western Blot: RIG-I Antibody (OTI6C1) [NBP2-45678]")
| Reactivity: | Human, Primate |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB |
![Western Blot: RIG-I AntibodyBSA Free [NBP2-27419]](https://resources.bio-techne.com/images/products/RIG-I-Antibody-Western-Blot-NBP2-27419-img0009.jpg "Western Blot: RIG-I AntibodyBSA Free [NBP2-27419]")
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG1 Monoclonal Clone #Alme-1 |
| Applications: | IHC, WB, IP |
![Western Blot: RIG-I Antibody (Alme-1)BSA Free [NBP2-80055]](https://resources.bio-techne.com/images/products/RIG-I-Antibody-Alme-1-Western-Blot-NBP2-80055-img0001.jpg "Western Blot: RIG-I Antibody (Alme-1)BSA Free [NBP2-80055]")
| Reactivity: | Human |
| Details: | Mouse IgM Monoclonal Clone #4G1B6 |
| Applications: | WB, ELISA, ICC/IF, Flow |
![Western Blot: RIG-I Antibody (4G1B6)BSA Free [NBP2-61849]](https://resources.bio-techne.com/images/products/RIG-I-Antibody-4G1B6-Western-Blot-NBP2-61849-img0005.jpg "Western Blot: RIG-I Antibody (4G1B6)BSA Free [NBP2-61849]")
| Reactivity: | Human |
| Details: | Mouse IgG2A Monoclonal Clone #OTI6C1 |
| Applications: | IHC, WB, ICC/IF |
![Western Blot: RIG-I Antibody (OTI6C1)Azide and BSA Free [NBP2-73909]](https://resources.bio-techne.com/images/products/RIG-I-Antibody-OTI6C1-Azide-and-BSA-Free-Western-Blot-NBP2-73909-img0002.jpg "Western Blot: RIG-I Antibody (OTI6C1)Azide and BSA Free [NBP2-73909]")
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Monoclonal Clone #2J8D5 |
| Applications: | WB, ELISA |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC |
![RIG-I Antibody Immunohistochemistry-Paraffin: RIG-I Antibody [NBP3-25330]](https://resources.bio-techne.com/images/products/nbp3-25330_rabbit-rig-i-pab-2012202314563424.jpg "Immunohistochemistry-Paraffin: RIG-I Antibody [NBP3-25330]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | ICC/IF |
![Immunocytochemistry/ Immunofluorescence: RIG-I Antibody [NBP2-55599]](https://resources.bio-techne.com/images/products/RIG-I-Antibody-Immunocytochemistry-Immunofluorescence-NBP2-55599-img0001.jpg "Immunocytochemistry/ Immunofluorescence: RIG-I Antibody [NBP2-55599]")
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #SR1042 |
| Applications: | WB, IP |
| Reactivity: | Human, Rat |
| Details: | Rabbit IgG Monoclonal Clone #3E1C6 |
| Applications: | WB, ELISA |
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #6K8P2 |
| Applications: | WB, ELISA |
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #7F6 |
| Applications: | IHC, ELISA |
![Immunohistochemistry: RIG-I Antibody (7F6) [NBP3-15174]](https://resources.bio-techne.com/images/products/RIG-I-Antibody-7F6-Immunohistochemistry-NBP3-15174-img0001.jpg "Immunohistochemistry: RIG-I Antibody (7F6) [NBP3-15174]")
![Western Blot: RIG-I Overexpression Lysate [NBL1-09808]](https://resources.bio-techne.com/images/products/DDX58-Overexpression-Lysate-Adult-Normal-Western-Blot-NBL1-09808-img0002.jpg "Western Blot: RIG-I Overexpression Lysate [NBL1-09808]")
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
