R-Spondin 2: Proteins and Enzymes

R-Spondin 2 (RSPO2, Roof plate-specific Spondin 2), also known as cysteine-rich and single thrombospondin domain containing protein 2 (Cristin 2), is a 33 kDa secreted protein that belongs to the R-Spondin family. The four known human R-Spondins regulate ß-catenin signaling and overlap in expression and function. Like other R-Spondins, R-Spondin 2 contains two adjacent cysteine-rich furin-like domains (aa 90-134) followed by a thrombospondin (TSP-1) motif (aa 144-204) and ...