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8 results for "POLR1A" in Products

POLR1A Products

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition

Reactivity: Human, Frog - Xenopus (African Clawed Frog)
Details: Rabbit IgG Polyclonal
Applications: ICC/IF
Immunocytochemistry/ Immunofluorescence: POLR1A Antibody [NBP2-56122]
Reactivity: Human
Details: Rabbit IgG Polyclonal
Applications: IHC
Immunohistochemistry-Paraffin: POLR1A Antibody [NBP2-32016]
(4)
Applications: AC
Reactivity: Human
Details: Rabbit IgG Polyclonal
Applications: WB, ELISA
POLR1A Antibody - BSA Free
Applications: AC
Reactivity: Human
Details: Rabbit IgG Polyclonal
Applications: WB, IP
POLR1A Antibody
Reactivity: Human
Details: Rabbit IgG Polyclonal
Applications: IP
POLR1A Antibody

RNA polymerase I inhibitor; also p53 pathway activator

Chemical Name: N-[2-(Dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide
Purity: ≥98% (HPLC)
RNA polymerase I inhibitor; also p53 pathway activator
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