2 results for "PERK Inhibitors" in Products
PERK Inhibitors Products
PKR-like ER kinase (PERK, EIF2AK3), EC 2.7.11.1, is a eukaryotic initiation factor 2α (elF2α) kinase that inhibits protein translation and is important in the endoplasmic reticulum (ER) stress response. PERK is localized to the ER and contains a stress-sensing domain that faces the ER lumen, a transmembrane segment, and a cytosolic kinase domain.
PERK plays an integral role in the unfolded protein response (UPR) and integrated stress response (ISR). The UPR and ISR are activated by a ...
Potent and selective PERK inhibitor; orally bioavailable
| Chemical Name: | 4-[2-Amino-4-methyl-3-(2-methyl-6-quinolinyl)benzoyl]-1,2-dihydro-1-methyl-2,5-diphenyl-3H-pyrazol-3-one hydrochloride |
| Purity: | ≥98% (HPLC) |
Potent and selective PERK inhibitor; orally bioavailable
| Chemical Name: | 1-[5-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-2,3-dihydro-1H-indol-1-yl]-2-[3-(trifluoromethyl)phenyl]ethanone |
| Purity: | ≥98% (HPLC) |
