Orexin R2/HCRTR2: Small Molecules and Peptides
Hypocretin receptor 2 (HCRTR2); also known as orexin receptor 2 or OX2R is a 40 kDa 7-transmembrane G-protein-coupled glycoprotein that is a high affinity receptor for orexins A and B (hypocretins 1 and 2). In mouse brain, engagement of HCRTRs promotes wakefulness, such that absence of either orexins or their receptors creates a narcolepsy-like state. HCRTR2 also influences reward circuits involving food or addictive drugs. The extracellular portions of human HCRTR2 share 92% and 93% aa identity with corresponding portions of mouse and rat HCRTR2, respectively.
7 results for "Orexin R2/HCRTR2 Small Molecules and Peptides" in Products
7 results for "Orexin R2/HCRTR2 Small Molecules and Peptides" in Products
Orexin R2/HCRTR2: Small Molecules and Peptides
Hypocretin receptor 2 (HCRTR2); also known as orexin receptor 2 or OX2R is a 40 kDa 7-transmembrane G-protein-coupled glycoprotein that is a high affinity receptor for orexins A and B (hypocretins 1 and 2). In mouse brain, engagement of HCRTRs promotes wakefulness, such that absence of either orexins or their receptors creates a narcolepsy-like state. HCRTR2 also influences reward circuits involving food or addictive drugs. The extracellular portions of human HCRTR2 share 92% and 93% aa identity with corresponding portions of mouse and rat HCRTR2, respectively.
Potent and selective OX2 agonist
| Purity: | ≥95% (HPLC) |
Potent, dual orexin receptor antagonist
| Chemical Name: | N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide |
| Purity: | ≥98% (HPLC) |
Potent, dual orexin receptor antagonist
| Chemical Name: | (2S)-N-(3,5-Dimethylphenyl)-1-[(4-methoxyphenyl)sulfonyl]-2-pyrrolidinecarboxamide |
| Purity: | ≥98% (HPLC) |
Selective OX2 antagonist
| Chemical Name: | N-(2,4-Dibromophenyl)-N'-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]-urea |
| Purity: | ≥98% (HPLC) |
Potent and selective OX2 antagonist
| Chemical Name: | (2S)-1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanone hydrochloride |
| Purity: | ≥98% (HPLC) |
Potent and selective OX2 agonist
| Chemical Name: | 3'-[[[3-[[2-[[2-(Dimethylamino)benzoyl]amino]ethyl]amino]phenyl]amino]sulfonyl]-4'-methoxy-N,N-dimethyl-[1,1'-biphenyl]-3-carboxamide dihydrochloride |
| Purity: | ≥98% (HPLC) |
Highly potent and selective OX2 antagonist; brain penetrant
| Chemical Name: | N-Ethyl-2-[(6-methoxy-3-pyridinyl)[(2-methylphenyl)sulfonyl]amino]-N-(3-pyridinylmethyl)-acetamide |
| Purity: | ≥98% (HPLC) |
