TCS OX2 29
Tocris Bioscience, part of Bio-Techne | Catalog # 3371
Potent and selective OX2 antagonist
Key Product Details
Description
Potent and selective OX2 antagonist
Product Description
TCS OX2 29 is a potent and selective OX2 receptor antagonist (IC50 = 40 nM). Displays >250-fold selectivity for OX2 over OX1 and a range of receptors, ion channels and transporters. Inhibits orexin A induced IP3 accumulation and ERK1/2 phosphorylation in CHO cells transfected with the OX2 receptor.Product Specifications
Molecular Weight
433.97
Formula
C23H31N3O3.HCl
Storage
Desiccate at +4°C
Purity
≥98% (HPLC)
Chemical Name
(2S)-1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanone hydrochloride
CAS Number
1610882-30-8
PubChem ID
53302033
InChI Key
NHKNHFJTMINMBP-ZMBIFBSDSA-N
SMILES
C[C@@](C)(C)[C@H](NCC3=CC=NC=C3)C(N(C2)CCC1=C2C=C(OC)C(OC)=C1)=O.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 43.4 | 100 | |
| DMSO | 10.85 | 25 |
Preparing Stock Solutions
for TCS OX2 29
The following data is based on the product molecular weight 433.97
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.30 mL | 11.52 mL | 23.04 mL |
| 5 mM | 0.46 mL | 2.30 mL | 4.61 mL |
| 10 mM | 0.23 mL | 1.15 mL | 2.30 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Mould Binding kinetics differentiates functional antagonism of orexin-2 receptor ligands. Br.J.Pharmacol. 2014 PMID: 23692283
- Hirose N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: The first orexin-2 receptor selective non-peptidic antagonist. Bioorg.Med.Chem.Lett. 2003 PMID: 14643355
Product Specific Notices for TCS OX2 29
For research use only
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