IL-1 RI: Small Molecules and Peptides
IL-1 RI, also known as the type 1 IL-1 receptor and CD121a, is a transmembrane protein in the Toll/IL-1 R (TIR) superfamily. IL-1 RI binds the pleiotropic cytokines IL-1 alpha and IL-1 beta, plus the IL-1 receptor antagonist (IL-1 Ra). Signal transduction requires complex formation with IL-1 R AcP/IL-1 R3. This complex recruits the adaptor protein MyD88, to initiate signaling in the NF kappa B pathway. IL-1 RI is expressed predominantly by T cells, fibroblasts, and endothelial cells and mediates acute phase inflammatory responses including fever.
Products:
2 results for "IL-1 RI Small Molecules and Peptides" in Products
2 results for "IL-1 RI Small Molecules and Peptides" in Products
IL-1 RI: Small Molecules and Peptides
IL-1 RI, also known as the type 1 IL-1 receptor and CD121a, is a transmembrane protein in the Toll/IL-1 R (TIR) superfamily. IL-1 RI binds the pleiotropic cytokines IL-1 alpha and IL-1 beta, plus the IL-1 receptor antagonist (IL-1 Ra). Signal transduction requires complex formation with IL-1 R AcP/IL-1 R3. This complex recruits the adaptor protein MyD88, to initiate signaling in the NF kappa B pathway. IL-1 RI is expressed predominantly by T cells, fibroblasts, and endothelial cells and mediates acute phase inflammatory responses including fever.
Products:
Potent, selective human type I IL-1 receptor antagonist
| Purity: | ≥95% (HPLC) |
TIR-TIR interaction inhibitor
| Chemical Name: | 1-Methyl-2,5-bis[[[(1S)-2-methyl-1-(1-pyrrolidinylcarbonyl)propyl](3-phenylpropyl)amino]carbonyl]pyridinium iodide |
| Purity: | ≥98% (HPLC) |
