AF 12198

Name: AF 12198
Brand: Tocris Bioscience
SKU: 1793
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1793

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Citations (7)

COA / SDS

Potent, selective human type I IL-1 receptor antagonist

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Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent, selective human type I IL-1 receptor antagonist

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Product Description

AF 12198 is a potent and selective antagonist for the human type I interleukin-1 (IL-1) receptor (IC₅₀ values are 8 nM, > 6.7 mM and > 200 mM for human type I, human type II and murine type I IL-1 receptors respectively). Blocks IL-1-induced expression of ICAM-1 and E-selectin in HUVECs and IL-1β induction of IL-8 in human dermal fibroblasts. Reduces IL-1β-induced IL-6 production and exhibits anti-inflammatory activity in vivo.

Product Specifications

Molecular Weight

1895.14

Formula

C₉₆H₁₂₃N₁₉O₂₂

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

185413-30-3

PubChem ID

90488713

InChI Key

VASLMBMCJADVGR-BRPRRQPRSA-N

SMILES

CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)C1CCN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CC1=CNC2=C1C=CC=C2)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CC1=CNC2=C1C=CC=C2)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC1=CC=CC=C1)NC(C)=O)[C@@H](C)O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in 10% ethanol/PBS

Calculators

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Background References

References are publications that support the biological activity of the product.

Akeson AF12198, a novel low molecular weight antagonist, selectively binds the human type I interleukin (IL)-1 receptor and blocks in vivo responses to IL-1. J.Biol.Chem. 1996 PMID: 8940020
Aimbire Low level laser therapy (LLLT) decreases pulmonary microvascular leakage, neutrophil influx and IL-1β levels in airway and lung from rat subjected to LPS-induced inflammation. Inflammation 2008 PMID: 18421573