4 results for "Huntingtin Small Molecules and Peptides" in Products
Huntingtin: Small Molecules and Peptides
Huntingtin protein (Htt) is a 348 kDa protein product of Huntington's disease (HD, IT15) gene. Huntington's disease is a neurodegenerative disorder caused by a mutation on the HD gene, producing a polyglutamin (polyQ) expansion on the N-terminus of Htt. The mutant Htt leads to cytotoxicity in the striatal neuron (1). This cytotoxicity is modulated by proteolytic cleavage with caspases and calpains, producing N-terminal polyQ fragments. A phosphorylation of Htt may also regulate the cleavage and ...
Potent, selective c-Raf1 kinase inhibitor
| Chemical Name: | 3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-dihydro-indol-2-one |
| Purity: | ≥95% (HPLC) |
β-secretase (BACE) inhibitor; inhibits amyloid assembly
| Alternate Names: | Epigallocatechin gallate |
| Chemical Name: | 3,4,5-Trihydroxybenzoic acid (2R,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester |
| Purity: | ≥98% (HPLC) |
Potent HTT pre-RNA splicing modulator
| Chemical Name: | 5-[(3R)-3-(Cyclopropylamino)-1-pyrrolidinyl]-N-(8-fluoro-2-methylimidazo[1,2-a]pyridin-6-yl)-2-pyrazinecarboxamide |
| Purity: | ≥98% (HPLC) |
Highly selective σ1 agonist
| Chemical Name: | 2-(4-Morpholinethyl) 1-phenylcyclohexanecarboxylate hydrochloride |
| Purity: | ≥99% (HPLC) |
