GABAA-rho Receptor Antagonists: Small Molecules and Peptides

GABA_A-ρ receptors are Cys-loop ionotropic ligand-gated ion channels mediating the fast synaptic inhibitory effects of GABA. They were previously known as GABA_C receptors, but IUPHAR now considers them to be a subtype of GABA_A receptors.

GABA_A-ρ receptors differ from other GABA_A receptors in pharmacology, physiology and biochemistry. Most GABA_A receptors are heteromeric pentamers, generally comprising two α, two β and one other subunit, whereas GABA_A-ρ receptors are ...