6 results for "GABA Transporter Inhibitors" in Products
GABA Transporter Inhibitors Products
GABA transporters are sodium- and chloride-dependent members of the solute carrier family 6 (SLC6) that mediate the rapid removal of GABA and maintain low extracellular levels. Four 12-TM domain transporters (GAT-1, GAT-2, GAT-3 and BGT-1) have been identified and localized to neurons and glia.
While GAT-1, GAT-2, GAT-3 and BGT-1 bind GABA with varying affinities, they share structural motifs including 12-TM domains, extracellular glycosylation sites and intracellular consensus sites for ...
Selective GAT-1 inhibitor
| Chemical Name: | 1,2,5,6-Tetrahydro-1-[2-[[(diphenylmethylene)amino]oxy]ethyl]-3-pyridinecarboxylic acid hydrochloride |
| Purity: | ≥98% (HPLC) |
GABA uptake inhibitor; also inhibits glutamate release and blocks NaV channels
| Chemical Name: | 2-Amino-6-trifluoromethoxybenzothiazole hydrochloride |
| Purity: | ≥98% (HPLC) |
Selective inhibitor of GAT-1
| Chemical Name: | 1-[2-[bis[4-(Trifluoromethyl)phenyl]methoxy]ethyl]-1,2,5,6-tetrahydropyridine-3-carboxylic acid hydrochloride |
| Purity: | ≥98% (HPLC) |
GABA uptake inhibitor
| Chemical Name: | 1-[2-[tris(4-methoxyphenyl)methoxy]ethyl]-(S)-3-piperidinecarboxylic acid |
| Purity: | ≥98% (HPLC) |
Potent GAT-1 inhibitor; brain penetrant
| Chemical Name: | 1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylic acid hydrochloride |
| Purity: | ≥98% (HPLC) |
Selective GAT-1 inhibitor; anticonvulsant
| Chemical Name: | (3R)-1-[4,4-Bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid hydrochloride |
| Purity: | ≥98% (HPLC) |
