9 results for "Ferroptosis Activators Small Molecules and Peptides" in Products
Ferroptosis Activators: Small Molecules and Peptides
Ferroptosis is a form of regulated cell death, distinct from apoptosis, necroptosis and autophagy. It is an iron-dependent process that results from the loss of glutathione peroxidase 4 (GPX4) activity, leading to accumulation of lipid peroxidation products and reactive oxygen species (ROS).
GPX4 is a selenoprotein that reduces hydrogen peroxide and lipid peroxides, while converting reduced glutathione (GSH) to its oxidized form; oxidized glutathione (glutathione disulfide) is recycled by ...
Mitochondrial VDAC modulator; also Ferroptosis activator
| Chemical Name: | 2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-quinazolinone |
| Purity: | ≥98% (HPLC) |
Ferroptosis activator
| Chemical Name: | N2,N7-Dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide |
| Purity: | ≥98% (HPLC) |
Inhibits glutathione peroxidase (GPX4); induces ferroptosis
| Chemical Name: | (1S,3R)-Methyl 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylate |
| Purity: | ≥98% (HPLC) |
Irreversible γ-glutamylcysteine synthetase (γ-GCS) inhibitor; induces ferroptosis
| Chemical Name: | (2S)-2-Amino-4-(S-butylsulfonimidoyl)butanoic acid |
| Purity: | ≥98% (HPLC) |
Inhibits glutathione peroxidase (GPX4); induces ferroptosis
| Chemical Name: | 2-[(Chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide |
| Purity: | ≥98% (HPLC) |
Selectively kills mutant HRAS-expressing cells; glutathione peroxidase inhibitor; induces ferroptosis
| Chemical Name: | [4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)methanone |
| Purity: | ≥98% (HPLC) |
HMG-CoA reductase inhibitor
| Chemical Name: | (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyly-2,2-dimethyl butanoate |
| Purity: | ≥98% (HPLC) |
Inhibitor of NF-κB activation; also inhibits SXC and folate transporter 1
| Chemical Name: | 5-[[4-(2-Pyridylsulfamoyl)phenyl]azo]salicylic acid |
| Purity: | ≥97% (HPLC) |
Negative control for 1S,3R-RSL3 (Cat. No. 6118)
| Chemical Name: | (1R,3R)-Methyl 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylate |
| Purity: | ≥98% (HPLC) |
