Erastin

Name: Erastin
Brand: Tocris Bioscience
SKU: 5449

Tocris Bioscience, part of Bio-Techne | Catalog # 5449

Citations (43)

COA / SDS

Mitochondrial VDAC modulator; also Ferroptosis activator

Key Product Details

Description:	Mitochondrial VDAC modulator; also Ferroptosis activator
Chemical Name:	2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-quinazolinone
Purity:	≥98% (HPLC)
Molecular Weight:	547.04

View Full Technical Details for Erastin

Technical Data
Citations

Biological Activity for Erastin

Erastin is an antitumor agent; selective for cells expressing oncogenic RAS. Activates ferroptosis; induces oxidative, non-apoptotic cell death in tumors by modulating mitochondrial voltage-dependent anion channels (VDAC). Cell permeable.

Compound Libraries for Erastin

Erastin is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Erastin

M. Wt	547.04
Formula	C₃₀H₃₁ClN₄O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	571203-78-6
PubChem ID	11214940
InChi Key	BKQFRNYHFIQEKN-UHFFFAOYSA-N
Smiles	O=C2C1=CC=CC=C1N=C(C(N4CCN(C(COC5=CC=C(Cl)C=C5)=O)CC4)C)N2C3=C(OCC)C=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Erastin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	10.94	20

Preparing Stock Solutions for Erastin

The following data is based on the product molecular weight 547.04.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	9.14 mL	45.70 mL	91.40 mL
1 mM	1.83 mL	9.14 mL	18.28 mL
2 mM	0.91 mL	4.57 mL	9.14 mL
10 mM	0.18 mL	0.91 mL	1.83 mL

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References for Erastin

References are publications that support the biological activity of the product.

Yagoda RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels. Nature 2007 PMID: 17568748
Dixon Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 2012 PMID: 22632970
Dolma Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. Cancer Cell 2003 PMID: 12676586