Erastin
Tocris Bioscience, part of Bio-Techne | Catalog # 5449
Mitochondrial VDAC modulator; also Ferroptosis activator
Key Product Details
Description
Mitochondrial VDAC modulator; also Ferroptosis activator
Product Description
Erastin is an antitumor agent; selective for cells expressing oncogenic RAS. Activates ferroptosis; induces oxidative, non-apoptotic cell death in tumors by modulating mitochondrial voltage-dependent anion channels (VDAC). Cell permeable.Product Specifications
Molecular Weight
547.04
Formula
C30H31ClN4O4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-quinazolinone
CAS Number
571203-78-6
PubChem ID
11214940
InChI Key
BKQFRNYHFIQEKN-UHFFFAOYSA-N
SMILES
O=C2C1=CC=CC=C1N=C(C(N4CCN(C(COC5=CC=C(Cl)C=C5)=O)CC4)C)N2C3=C(OCC)C=CC=C3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 10.94 | 20 |
Preparing Stock Solutions
for Erastin
The following data is based on the product molecular weight 547.04
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 9.14 mL | 45.70 mL | 91.40 mL |
| 1 mM | 1.83 mL | 9.14 mL | 18.28 mL |
| 2 mM | 0.91 mL | 4.57 mL | 9.14 mL |
| 10 mM | 0.18 mL | 0.91 mL | 1.83 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Yagoda RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels. Nature 2007 PMID: 17568748
- Dixon Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 2012 PMID: 22632970
- Dolma Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. Cancer Cell 2003 PMID: 12676586
Product Specific Notices for Erastin
For research use only
Loading...
Loading...