Draxin: Proteins and Enzymes

Draxin (Dorsal repulsive axon guidance protein; also neucrin) is a secreted, 58 kDa, presumable glycoprotein member of the draxin family of repulsive guidance proteins. In mammals, it is expressed in neurons (axons), astroglia, and likely cells of the developing somite. Draxin acts as a Wnt antagonist by binding to LRP6. The net effect is to block neural crest migration, and promote the organization of axons into functional tracts or bundles (fasciculation).