12 results for "CDK4 Small Molecules and Peptides" in Products

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CDK4 Small Molecules and Peptides

Cyclin-dependent Kinase 4 (CDK4) is a 303 amino acid (aa) member of the Ser/Thr kinase family with a predicted molecular weight of 33.7 kDa. The human protein shares 94% and 95% aa sequence identity with the mouse and rat orthologs, respectively. CDK4 shuttles between the cytoplasm and nucleus as part of its role in cell cycle regulation. It promotes the transition from G1 to S phase by phosphorylating and inactivating RB1. Activation of CDK4 requires binding of a D-type Cyclin and ...

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GF 109203X
Catalog #: 0741
(1)
Citations (311)
Product Documents
Images (1)

Protein kinase C inhibitor

Alternate Names:
Gö 6850,Bisindolylmaleimide I
Chemical Name:
2-[1-(3-Dimethylaminopropyl)indol-3-yl]-3-(indol-3-yl) maleimide
Purity:
≥98%
Protein kinase C inhibitor
Catalog #
Availability
Size / Price
Qty
0741/1
0741/10
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PD 0332991 isethionate
Catalog #: 4786
Citations (21)
Product Documents
Images (1)

Potent cdk4 and cdk6 inhibitor; brain penetrant

Alternate Names:
Palbociclib
Chemical Name:
6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one isethionate salt
Purity:
≥98%
Potent cdk4 and cdk6 inhibitor; brain penetrant
Catalog #
Availability
Size / Price
Qty
4786/50
4786/10
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AZD 5438
Catalog #: 3968
Citations (13)
Product Documents
Images (1)

Cdk inhibitor; potently inhibits cdk1, 2, 5 and 9

Chemical Name:
4-[2-Methyl-1-(1-methylethyl)-1H-imidazol-5-yl]-N-[4-(methylsulfonyl)phenyl]-2-pyrimidinamine
Purity:
≥98%
Cdk inhibitor; potently inhibits cdk1, 2, 5 and 9
Catalog #
Availability
Size / Price
Qty
3968/50
3968/10
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Flavopiridol hydrochloride
Catalog #: 3094
Citations (10)
Product Documents
Images (1)

Cdk inhibitor; potently inhibits cdk2 and cdk9

Alternate Names:
L 86-8275
Chemical Name:
2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one hydrochloride
Purity:
≥98%
Cdk inhibitor; potently inhibits cdk2 and cdk9
Catalog #
Availability
Size / Price
Qty
3094/10
3094/50
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Lovastatin
Catalog #: 1530
(1)
Citations (40)
Product Documents
Images (1)

Potent HMG-CoA reductase inhibitor

Alternate Names:
Mevinolin
Chemical Name:
(2S)-(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl-2-methyl butanoate
Purity:
≥97%
Potent HMG-CoA reductase inhibitor
Catalog #
Availability
Size / Price
Qty
1530/10
1530/50
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Simvastatin
Catalog #: 1965
(1)
Citations (37)
Product Documents
Images (1)

HMG-CoA reductase inhibitor

Chemical Name:
(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyly-2,2-dimethyl butanoate
Purity:
≥98%
HMG-CoA reductase inhibitor
Catalog #
Availability
Size / Price
Qty
1965/50
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Ryuvidine
Catalog #: 2609
Citations (3)
Product Documents
Images (1)

SETD8 inhibitor; also CDK4 inhibitor

Chemical Name:
2-Methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione
Purity:
≥98%
SETD8 inhibitor; also CDK4 inhibitor
Catalog #
Availability
Size / Price
Qty
2609/10
2609/50
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R 547
Catalog #: 5494
Product Documents
Images (1)

Potent and selective cdk inhibitor; orally bioavailable

Chemical Name:
[4-Amino-2-[[1-(methylsulfonyl)-4-piperidinyl]amino]-5-pyrimidinyl](2,3-difluoro-6-methoxyphenyl)methanone
Purity:
≥98%
Potent and selective cdk inhibitor; orally bioavailable
Catalog #
Availability
Size / Price
Qty
5494/10
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BSJ-03-204
Catalog #: 6938
Citations (1)
Product Documents
Images (1)

Selective Cdk4/6 Degrader (PROTAC®

Chemical Name:
N-[4-[4-[6-[(6-Acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]butyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide
Purity:
≥98%
Selective Cdk4/6 Degrader (PROTAC®)
Catalog #
Availability
Size / Price
Qty
6938/5
Bulk Order

Ribociclib
Catalog #: 7050
Citations (5)
Product Documents
Images (1)

Dual cdk4/cdk6 inhibitor; orally bioavailable

Alternate Names:
LEE-011
Chemical Name:
7-Cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Purity:
≥98%
Dual cdk4/cdk6 inhibitor; orally bioavailable
Catalog #
Availability
Size / Price
Qty
7050/50
Bulk Order

HEMTAC 26
Catalog #: 7940
Product Documents
Images (1)

CDK6 and CDK4 HSP90-mediated targeting chimera (HEMTAC) Degrader

Chemical Name:
4-[6-[(6-Acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-N-[[1-[4-[2-amino-4-chloro-7-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-3-butyn-1-yl]-1H-1,2,3-triazol-4-yl]methyl]-1-piperazineacetamide
Purity:
≥95%
CDK6 and CDK4 HSP90-mediated targeting chimera (HEMTAC) Degrader
Catalog #
Availability
Size / Price
Qty
7940/5
Bulk Order

HEMTAC 26
Catalog #: 7940
Product Documents
Images (1)

CDK6 and CDK4 HSP90-mediated targeting chimera (HEMTAC) Degrader

Chemical Name:
4-[6-[(6-Acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-N-[[1-[4-[2-amino-4-chloro-7-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-3-butyn-1-yl]-1H-1,2,3-triazol-4-yl]methyl]-1-piperazineacetamide
Purity:
≥95%
CDK6 and CDK4 HSP90-mediated targeting chimera (HEMTAC) Degrader
Catalog #
Availability
Size / Price
Qty
7940/5
Bulk Order
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