Ryuvidine
Tocris Bioscience, part of Bio-Techne | Catalog # 2609
SETD8 inhibitor; also CDK4 inhibitor
Key Product Details
Description
SETD8 inhibitor; also CDK4 inhibitor
Product Description
Ryuvidine is an inhibitor of SETD8 protein lysine methyltransferase (PKMT) (IC50 = 0.5 μM); suppresses H4K20 monomethylation in vitro. Also inhibits cyclin-dependent kinase (CDK) 4 (IC50 = 6.0 μM at CDK4/cyclin D1). Induces S phase accumulation in HEK293T cells. Cytotoxic against a range of human cancer cells.Product Specifications
Molecular Weight
284.33
Formula
C15H12N2O2S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2-Methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione
CAS Number
265312-55-8
PubChem ID
481747
InChI Key
HFPLHASLIOXVGS-UHFFFAOYSA-N
SMILES
CC1=NC2=C(S1)C(=O)C=C(NC1=CC=C(C)C=C1)C2=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 5.69 | 20 | |
| Ethanol | 1.42 | 5 |
Preparing Stock Solutions
for Ryuvidine
The following data is based on the product molecular weight 284.33
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 17.59 mL | 87.93 mL | 175.85 mL |
| 1 mM | 3.52 mL | 17.59 mL | 35.17 mL |
| 2 mM | 1.76 mL | 8.79 mL | 17.59 mL |
| 10 mM | 0.35 mL | 1.76 mL | 3.52 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Blum Small-molecule inhibitors of SETD8 with cellular activity. ASC.Chem.Biol. [Epub ahead of print] 2014 PMID: 25137013
- Ryu 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents. Bioorg.Med.Chem.Lett. 2000 PMID: 10743948
Product Specific Notices for Ryuvidine
For research use only
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