Ryuvidine

Name: Ryuvidine
Brand: Tocris Bioscience
SKU: 2609

Tocris Bioscience, part of Bio-Techne | Catalog # 2609

Citations (3)

COA / SDS

SETD8 inhibitor; also CDK4 inhibitor

Key Product Details

Description:	SETD8 inhibitor; also CDK4 inhibitor
Chemical Name:	2-Methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione
Purity:	≥98% (HPLC)
Molecular Weight:	284.33

View Full Technical Details for Ryuvidine

Technical Data
Citations

Biological Activity for Ryuvidine

Ryuvidine is an inhibitor of SETD8 protein lysine methyltransferase (PKMT) (IC₅₀ = 0.5 μM); suppresses H4K20 monomethylation in vitro. Also inhibits cyclin-dependent kinase (CDK) 4 (IC₅₀ = 6.0 μM at CDK4/cyclin D1). Induces S phase accumulation in HEK293T cells. Cytotoxic against a range of human cancer cells.

Compound Libraries for Ryuvidine

Ryuvidine is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for Ryuvidine

M. Wt	284.33
Formula	C₁₅H₁₂N₂O₂S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	265312-55-8
PubChem ID	481747
InChi Key	HFPLHASLIOXVGS-UHFFFAOYSA-N
Smiles	CC1=NC2=C(S1)C(=O)C=C(NC1=CC=C(C)C=C1)C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ryuvidine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	5.69	20
	ethanol	1.42	5

Preparing Stock Solutions for Ryuvidine

The following data is based on the product molecular weight 284.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	17.59 mL	87.93 mL	175.85 mL
1 mM	3.52 mL	17.59 mL	35.17 mL
2 mM	1.76 mL	8.79 mL	17.59 mL
10 mM	0.35 mL	1.76 mL	3.52 mL

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References for Ryuvidine

References are publications that support the biological activity of the product.

Blum Small-molecule inhibitors of SETD8 with cellular activity. ASC.Chem.Biol. [Epub ahead of print] 2014 PMID: 25137013
Ryu 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents. Bioorg.Med.Chem.Lett. 2000 PMID: 10743948