Caspase-4 Products
Caspase-11 (also known as Caspase-4) is a cysteine-aspartic acid protease that functions in apoptosis initiation and the activation of proinflammatory cytokines. Pro-Caspase-11 is expressed as a zymogen which is cleaved into two subunits, p20 and p10. It is activated by an autocatalytic mechanism or by Caspase-8 mediated cleavage in response to ER stress or bacterial infection. Its expression and activation can be induced by exposure to LPS. Caspase-11 is one of several caspases associated with the inflammasome and plays an important role in the activation of proinflammatory cytokines. The active enzyme can cleave and activate Caspase-1 which in turn activates IL-1 beta.
Products:
142 results for "Caspase-4" in Products
142 results for "Caspase-4" in Products
Caspase-4 Products
Caspase-11 (also known as Caspase-4) is a cysteine-aspartic acid protease that functions in apoptosis initiation and the activation of proinflammatory cytokines. Pro-Caspase-11 is expressed as a zymogen which is cleaved into two subunits, p20 and p10. It is activated by an autocatalytic mechanism or by Caspase-8 mediated cleavage in response to ER stress or bacterial infection. Its expression and activation can be induced by exposure to LPS. Caspase-11 is one of several caspases associated with the inflammasome and plays an important role in the activation of proinflammatory cytokines. The active enzyme can cleave and activate Caspase-1 which in turn activates IL-1 beta.
Products:
High affinity and selective caspase-4 and caspase 1/ICE inhibitor; orally bioavailable
| Alternate Names: | Belnacasan |
| Chemical Name: | N-(4-Amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl]-L-prolinamide |
| Purity: | ≥98% (HPLC) |
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, ICC/IF |
![Immunocytochemistry/ Immunofluorescence: Caspase-4 Antibody [NBP1-87681]](https://resources.bio-techne.com/images/products/Caspase-4-Antibody-Immunocytochemistry-Immunofluorescence-NBP1-87681-img0005.jpg "Immunocytochemistry/ Immunofluorescence: Caspase-4 Antibody [NBP1-87681]")
| Reactivity: | Human, Bacteria - Escherichia coli |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ELISA, ICC/IF |
![Western Blot: Caspase-4 AntibodyBSA Free [NBP1-77208]](https://resources.bio-techne.com/images/products/Caspase-4-Antibody-Western-Blot-NBP1-77208-img0001.jpg "Western Blot: Caspase-4 AntibodyBSA Free [NBP1-77208]")
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
![Western Blot: Caspase-4 AntibodyAzide and BSA Free [NBP3-05650]](https://resources.bio-techne.com/images/products/Caspase-4-Antibody-Western-Blot-NBP3-05650-img0001.jpg "Western Blot: Caspase-4 AntibodyAzide and BSA Free [NBP3-05650]")
| Reactivity: | Human |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #7G7 |
| Applications: | WB, ELISA |
![Western Blot: Caspase-4 Antibody (7G7) [H00000837-M02-100ug]](https://resources.bio-techne.com/images/products/Caspase-4-Antibody-7G7-Western-Blot-H00000837-M02-100ug-img0004.jpg "Western Blot: Caspase-4 Antibody (7G7) [H00000837-M02-100ug]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
![Western Blot: Caspase-4 Antibody [NBP3-13397]](https://resources.bio-techne.com/images/products/Caspase-4-Antibody-Western-Blot-NBP3-13397-img0002.jpg "Western Blot: Caspase-4 Antibody [NBP3-13397]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ELISA |
| Applications: | WB, ELISA, MA, AP |
![SDS-PAGE: Recombinant Human Caspase-4 GST (N-Term) Protein [H00000837-P01]](https://resources.bio-techne.com/images/products/Recombinant-Human-Caspase-4-Protein-SDS-Page-H00000837-P01-img0001.jpg "SDS-PAGE: Recombinant Human Caspase-4 GST (N-Term) Protein [H00000837-P01]")
Potent and selective inhibitor of caspases 1, 5 and 4
| Purity: | ≥95% (HPLC) |
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #OTI4A2 |
| Applications: | WB |
![Western Blot: Caspase-4 Antibody (OTI4A2) [NBP2-46065]](https://resources.bio-techne.com/images/products/Caspase-4-Antibody-4A2-Western-Blot-NBP2-46065-img0001.jpg "Western Blot: Caspase-4 Antibody (OTI4A2) [NBP2-46065]")
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | ICC/IF |
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | ICC/IF |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, ELISA |
![Western Blot: Caspase-4 Antibody [NB300-901]](https://resources.bio-techne.com/images/products/Caspase-4-Antibody-Western-Blot-NB300-901-img0001.jpg "Western Blot: Caspase-4 Antibody [NB300-901]")
| Applications: | WB |
![Western Blot: Caspase-4 Overexpression Lysate [NBL1-08712]](https://resources.bio-techne.com/images/products/Caspase-4-Overexpression-Lysate-Adult-Normal-Western-Blot-NBL1-08712-img0002.jpg "Western Blot: Caspase-4 Overexpression Lysate [NBL1-08712]")
| Applications: | WB |
![Western Blot: Caspase-4 Overexpression Lysate [NBL1-08713]](https://resources.bio-techne.com/images/products/Caspase-4-Overexpression-Lysate-Adult-Normal-Western-Blot-NBL1-08713-img0002.jpg "Western Blot: Caspase-4 Overexpression Lysate [NBL1-08713]")
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #OTI4A2 |
| Applications: | WB |
![Western Blot: Caspase-4 Antibody (OTI4A2)Azide and BSA Free [NBP2-70339]](https://resources.bio-techne.com/images/products/Caspase-4-Antibody-OTI4A2-Azide-and-BSA-Free-Western-Blot-NBP2-70339-img0001.jpg "Western Blot: Caspase-4 Antibody (OTI4A2)Azide and BSA Free [NBP2-70339]")
| Applications: | AC |
| Applications: | AC |
| Applications: | AC |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | ICC/IF |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #OTI4A2 |
| Applications: | WB |