BMP-2: Proteins and Enzymes
BMP-2 (Bone morphogenetic protein 2) is a TGF-beta superfamily cytokine that plays a dominant role in embryonic dorsal-ventral patterning, organogenesis, limb bud formation, and bone formation and regeneration. BMP-2 forms disulfide linked homodimers and heterodimers with BMP-7. BMP-2 signals through heterodimeric complexes of type I receptors (ActiRI, BMPR-IA, or BMPR-IB) and type II receptors (BMP RII or ActRIIB).
It induces chondrocyte proliferation, endochondral bone formation, longitudinal bone growth, and bone and cartilage repair. BMP-2/BMP-7 heterodimers are significantly more potent than BMP-2 homodimers at inducing bone formation in vivo. BMP-2 also promotes the maintenance and repair of colonic epithelium, suppresses neuronal dopamine synthesis and release, induces apoptosis in medulloblastoma cells, and is required for cardiac contractility.
Products:
8 results for "BMP-2 Proteins and Enzymes" in Products
8 results for "BMP-2 Proteins and Enzymes" in Products
BMP-2: Proteins and Enzymes
BMP-2 (Bone morphogenetic protein 2) is a TGF-beta superfamily cytokine that plays a dominant role in embryonic dorsal-ventral patterning, organogenesis, limb bud formation, and bone formation and regeneration. BMP-2 forms disulfide linked homodimers and heterodimers with BMP-7. BMP-2 signals through heterodimeric complexes of type I receptors (ActiRI, BMPR-IA, or BMPR-IB) and type II receptors (BMP RII or ActRIIB).
It induces chondrocyte proliferation, endochondral bone formation, longitudinal bone growth, and bone and cartilage repair. BMP-2/BMP-7 heterodimers are significantly more potent than BMP-2 homodimers at inducing bone formation in vivo. BMP-2 also promotes the maintenance and repair of colonic epithelium, suppresses neuronal dopamine synthesis and release, induces apoptosis in medulloblastoma cells, and is required for cardiac contractility.
Products:
| Source: | E. coli |
| Accession #: | P12643 |
| Applications: | BA |
| Source: | CHO |
| Accession #: | P12643 |
| Applications: | BA |
| Source: | CHO |
| Accession #: | P12643.1 |
| Applications: | BA |
| Source: | E. coli |
| Accession #: | NP_001191 (BMP-2) & NP_001710 (BMP-7) |
| Applications: | BA |
| Source: | E. coli |
| Accession #: | P12643 (BMP-2) & P22004 (BMP-6) |
| Applications: | BA |
| Source: | E. coli |
| Accession #: | AAI63048.1 |
| Applications: | BA |
| Applications: | PAGE, Bioactivity |
![SDS-PAGE: Recombinant Human BMP-2 Protein [NBP2-34928]](https://resources.bio-techne.com/images/products/Human-BMP-2-Protein-SDS-Page-NBP2-34928-img0001.jpg "SDS-PAGE: Recombinant Human BMP-2 Protein [NBP2-34928]")