BCR: Small Molecules and Peptides
BCR (Breakpoint cluster region protein) is a novel 155-165 kDa Ser/Thr protein kinase. It is found in fibroblasts and hematopoietic cells, interacts with 14-3-3, and serves as a natural inhibitor of the growth factor-associated c-Abl nonreceptor protein tyrosine kinase. Human BCR is 1271 amino acids (aa) in length. It contains a coiled-coil dimerization motif (aa 28-68), a Ser/Thr kinase region (aa 176-426), one DH domain (aa 498-691) and a Rho-Gap region (aa 1054-1248). The N-terminal aa 1-902 and 1-927 are known to contribute to the BCR/ABL oncoprotein. BCR likely forms homodimers and 650 kDa homotetramers. An alternate start site exists at Met498, while other isoforms show a deletion of aa 961-1004, plus a 61 and 37 aa substitution for aa 1-488. Over aa 1-426, human BCR is 89% aa identical to mouse BCR.
2 results for "BCR Small Molecules and Peptides" in Products
2 results for "BCR Small Molecules and Peptides" in Products
BCR: Small Molecules and Peptides
BCR (Breakpoint cluster region protein) is a novel 155-165 kDa Ser/Thr protein kinase. It is found in fibroblasts and hematopoietic cells, interacts with 14-3-3, and serves as a natural inhibitor of the growth factor-associated c-Abl nonreceptor protein tyrosine kinase. Human BCR is 1271 amino acids (aa) in length. It contains a coiled-coil dimerization motif (aa 28-68), a Ser/Thr kinase region (aa 176-426), one DH domain (aa 498-691) and a Rho-Gap region (aa 1054-1248). The N-terminal aa 1-902 and 1-927 are known to contribute to the BCR/ABL oncoprotein. BCR likely forms homodimers and 650 kDa homotetramers. An alternate start site exists at Met498, while other isoforms show a deletion of aa 961-1004, plus a 61 and 37 aa substitution for aa 1-488. Over aa 1-426, human BCR is 89% aa identical to mouse BCR.
Selective allosteric inhibitor of Bcr-Abl; analog of GNF 2 (Cat. No. 4399)
| Chemical Name: | N-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide |
| Purity: | ≥98% (HPLC) |
Potent multi-kinase and pan-Bcr-Abl inhibitor
| Alternate Names: | Ponatinib |
| Chemical Name: | 3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzamide |
| Purity: | ≥98% (HPLC) |
