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Bcl-2 Family Inhibitors: Small Molecules and Peptides

10 results for "Bcl-2 Family Inhibitors Small Molecules and Peptides" in Products

10 results for "Bcl-2 Family Inhibitors Small Molecules and Peptides" in Products

Bcl-2 Family Inhibitors: Small Molecules and Peptides

Bcl-2 family inhibitor; mimics BH3 and induces apoptosis in cancer cell lines

Chemical Name: 4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide
Purity: ≥98% (HPLC)
Bcl-2 family inhibitor; mimics BH3 and induces apoptosis in cancer cell lines

High affinity Bcl-2 family inhibitor; proapoptotic, senolytic and antitumor

Chemical Name: 4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide
Purity: ≥98% (HPLC)
High affinity Bcl-2 family inhibitor; proapoptotic, senolytic and antitumor

Inhibitor of Bcl-2 family members; antiapoptotic

Alternate Names: GX15-070
Chemical Name: 2-[2-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl]-1H-indole methanesulfonate
Purity: ≥98% (HPLC)
Inhibitor of Bcl-2 family members; antiapoptotic

Selective, high affinity Bcl-2 inhibitor; orally bioavailable

Alternate Names: Venetoclax,GDC-0199
Chemical Name: 4-[4-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide
Purity: ≥98% (HPLC)
Selective, high affinity Bcl-2 inhibitor; orally bioavailable

Allosteric inhibitor of Bax channel activation

Alternate Names: BAI1
Chemical Name: 3,6-Dibromo-α-(1-piperazinylmethyl)-9H-carbazole-9-ethanol dihydrochloride
Purity: ≥98% (HPLC)
Allosteric inhibitor of Bax channel activation

Potent and selective kinesin spindle protein (KSP) inhibitor; induces Mcl-1 degradation

Alternate Names: Filanesib
Chemical Name: (2S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide trifluoroacetate
Purity: ≥98% (HPLC)
Potent and selective kinesin spindle protein (KSP) inhibitor; induces Mcl-1 degradation

Potent and selective Bcl-xL inhibitor; antitumor and inducer of apoptosis

Chemical Name: 6-[8-[(2-Benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-3-[5-methyl-1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-1H-pyrazol-4-yl]-2-pyridinecarboxylic acid
Purity: ≥98% (HPLC)
Potent and selective Bcl-xL inhibitor; antitumor and inducer of apoptosis

Glucocorticoid receptor agonist

Chemical Name: 11β,17β,21-Trihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione
Purity: ≥98% (HPLC)
Glucocorticoid receptor agonist

High affinity and selective activator of Bax

Chemical Name: 2-[(2-Nitro-9H-fluorene-9-ylidene)methyl]phenol
Purity: ≥98% (HPLC)
High affinity and selective activator of Bax

Molecular glue; induces degradation of BCL6

Chemical Name: rel-5-[[5-Chloro-2-[(3R,5S)-4,4-difluoro-3,5-dimethyl-1-piperidinyl]-4-pyrimidinyl]amino]-1,3-dihydro-3-(3-hydroxy-3-methylbutyl)-1-methyl-2H-benzimidazol-2-one
Purity: ≥98% (HPLC)
Molecular glue; induces degradation of BCL6
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