Angiopoietin-like Protein 4/ANGPTL4: Proteins and Enzymes

Angiopoietin-like 4 (ANGPTL4), also known as FIAF, FARP, and PGAR, is a 55 kDa glycoprotein secreted by the liver and fat tissue. It contains an N-terminal coiled coil domain and a C-terminal fibrinogen-like domain which can be proteolytically separated. The coiled coil domain mediates the formation of variable sized disulfide-linked oligomers. This domain directly inhibits lipoprotein lipase (LPL), resulting in increased circulating triglyceride levels. ANGPTL4 circulates in association with ...