This application note demonstrates how the Maurice™ system enables robust characterization of antibody-drug conjugates (ADCs) through charge and size-based analysis:
- icIEF on Maurice provides high-resolution charge heterogeneity analysis, less impacted by linker-drug effects compared to IEX
- The system’s On-Board Mixing (OBM) feature preserves pH-sensitive samples (likely from linkers but could be from mAb or payload) and by minimizing pre-injection degradation
- CE-SDS on Maurice delivers low-fragmentation and high-throughput analysis of ADC size and purity
- ADC payloads with blue Fluorescence can be detected using Maurice’s 458 nm fluorescence filter
