Let Maurice and MFI Characterize Your Vaccine Products
ProteinSimple’s next-gen platforms provide solutions for characterizing vaccine products with speed, accuracy, and reliability, so you can get safe, effective products to market, faster.
Maurice, our automated capillary electrophoresis (CE) platform, combines imaged capillary isoelectric focusing (icIEF) and capillary electrophoresis sodium dodecyl sulfate (CE-SDS) detection modes in one compact, easy-to-use instrument. With Maurice, you get reproducible, high-quality data to get charge heterogeneity, purity, and identity of proteins and delivery vectors for vaccines, such as lipid nanoparticles for mRNA vaccines, as seen in those approved for market for COVID-19.
Micro-Flow Imaging (MFI), accurately and precisely detects subvisible particles in solution, enabling direct detection of aggregates and contaminants in vaccine products, which can be critical for ensuring safety and efficacy. The MFI 5000 series can be automated with our Bot1 autosampler, enabling walk-away time, freeing you to deal with more important tasks.
Analytical Tools For The Fight Against COVID-19
The emergence of COVID-19 and the ensuing pandemic has meant that safe, fast, and effective vaccine development has never been more critical. View this webinar to learn about the analytical platforms that ProteinSimple has to offer to arm researchers with the tools needed to combat this virus.
Analytical Solutions For Vaccine Development
Learn how researchers at Merck and Medgene use Maurice and other ProteinSimple platforms to assess proteins used in vaccine development for critical quality attributes such as identity and purity, in this on-demand webinar.
Characterization Of LNPS With Maurice
See how researchers at Merck used Maurice to measure the surface charge of an LNP-based mRNA vaccine, in order to confirm identity for manufacturing as well as process and formulation development in this paper, “Development of an Imaged Capillary Isoelectric Focusing Method for Characterizing the Surface Charge of mRNA Lipid Nanoparticle Vaccines.”
Researchers at the Institute of Medicinal and Pharmaceutical Chemistry at the University of Braunschweig used Maurice cIEF to evaluate the isoelectric point (pI) of various SARS-CoV-2 proteins and confirm the theoretical pI ranges derived from the amino acid sequences of these proteins.
See how icIEF with fluorescence detection on Maurice is used to characterize a common carrier protein for polysaccharide conjugate-based vaccines in the paper, “Quantitation of CRM197 Using Imaged Capillary Isoelectric Focusing With Fluorescence Detection and Capillary Western.”
Microcarriers are used to increase bioreactor surface area for growing cell-culture derived vaccines. Learn how researchers used MFI to determine cell coverage and confluency on these microcarriers in the publication: “Cell Confluency Analysis on Microcarriers by Micro-Flow Imaging.”
In the paper, “Impact of Formulation and Suspension Properties on Redispersion of Aluminum-Adjuvanted Vaccines,” MFI was used to assess the resuspendability of aluminum adjuvant-containing vaccines based on different formulation conditions.
Researchers used MFI to assess protein aggregation in the manufacturing of hyaluronan-based dissolving microneedles for intradermal vaccination. Read the paper, “Hyaluronan-Based Dissolving Microneedles With High Antigen Content for Intradermal Vaccination: Formulation, Physicochemical Characterization and Immunogenicity Assessment” to learn how.