P3S

Name: P3S
Brand: Tocris Bioscience
SKU: 7974

Tocris Bioscience, part of Bio-Techne | Catalog # 7974

COA / SDS

Reagent for modifying RNA at 2'-OH position, for SHAPE-MAP experiments

Key Product Details

Description:	Reagent for modifying RNA at 2'-OH position, for SHAPE-MAP experiments
Chemical Name:	3-((1H-1,2,4-Triazol-1-yl)sulfonyl)pyridine
Purity:	≥95% (HPLC)
Molecular Weight:	210.21

View Full Technical Details for P3S

Technical Data
Citations

Biological Activity for P3S

P3S is a pyridine sulfonyl triazole able to modify RNA via RNA 2'-OH sulfonylation. P3S can be used for RNA SHAPE-MaP experiments in cell lines or live bacteria. It is stable in aqueous media (with half-lives of several hours) even at room temperature.

Technical Data for P3S

M. Wt	210.21
Formula	C₇H₆N₄O₂S
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2988852-68-0
InChi Key	LBQFWDRVXUJAAR-UHFFFAOYSA-N
Smiles	O=S(C1=CC=CN=C1)(N2C=NC=N2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for P3S

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	21.02	100

Preparing Stock Solutions for P3S

The following data is based on the product molecular weight 210.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.76 mL	23.79 mL	47.57 mL
5 mM	0.95 mL	4.76 mL	9.51 mL
10 mM	0.48 mL	2.38 mL	4.76 mL
50 mM	0.10 mL	0.48 mL	0.95 mL

Molarity Calculator

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Reconstitution Calculator

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References for P3S

References are publications that support the biological activity of the product.

Chatterjee Sulfonylation of RNA 2'-OH groups. ACS Cent.Sci. 2023 PMID: 36968531

P3S