ZXH 3-26
Tocris Bioscience, part of Bio-Techne | Catalog # 6713
Potent and selective BRD4 Degrader (PROTAC®)
Discontinued Product
6713 has been discontinued.
View all Active Degraders products.
Key Product Details
Description
Potent and selective BRD4 Degrader (PROTAC®)
Product Description
ZXH 3-26 is a potent and selective BRD4 Degrader (PROTAC®) (DC50 ~ 5 nM). Exhibits no significant degradation of BRD2 and BRD3. Whole proteome mass spectometry shows significant downregulation of BRD4 only. Active intracellularly.PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Licensing Information
Sold under license from Dana-Farber Cancer Institute.Product Specifications
Molecular Weight
785.27
Formula
C38H37ClN8O7S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
Methyl (6S)-4-(4-chlorophenyl)-2-[[[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]pentyl]amino]carbonyl]-3,9-dimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetate
CAS Number
2243076-67-5
PubChem ID
132427808
InChI Key
OTKOFICOCDRNDA-PMCHYTPCSA-N
SMILES
COC(C[C@@H]1N=C(C2=CC=C(C=C2)Cl)C3=C(N4C(C)=NN=C14)SC(C(NCCCCCNC5=C6C(N(C(C6=CC=C5)=O)C7CCC(NC7=O)=O)=O)=O)=C3C)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 78.53 | 100 |
Preparing Stock Solutions
for ZXH 3-26
The following data is based on the product molecular weight 785.27
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.27 mL | 6.37 mL | 12.73 mL |
| 5 mM | 0.25 mL | 1.27 mL | 2.55 mL |
| 10 mM | 0.13 mL | 0.64 mL | 1.27 mL |
| 50 mM | 0.03 mL | 0.13 mL | 0.25 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Nowak Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat.Chem.Biol. 2018 PMID: 29892083
Product Specific Notices for ZXH 3-26
For research use only
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